The two origins of hemocytes in Drosophila - PubMed (original) (raw)
. 2003 Oct;130(20):4955-62.
doi: 10.1242/dev.00702. Epub 2003 Aug 20.
Affiliations
- PMID: 12930778
- DOI: 10.1242/dev.00702
The two origins of hemocytes in Drosophila
Anne Holz et al. Development. 2003 Oct.
Abstract
As in many other organisms, the blood of Drosophila consists of several types of hemocytes, which originate from the mesoderm. By lineage analyses of transplanted cells, we specified two separate anlagen that give rise to different populations of hemocytes: embryonic hemocytes and lymph gland hemocytes. The anlage of the embryonic hemocytes is restricted to a region within the head mesoderm between 70 and 80% egg length. In contrast to all other mesodermal cells, the cells of this anlage are already determined as hemocytes at the blastoderm stage. Unexpectedly, these hemocytes do not degenerate during late larval stages, but have the capacity to persist through metamorphosis and are still detectable in the adult fly. A second anlage, which gives rise to additional hemocytes at the onset of metamorphosis, is located within the thoracic mesoderm at 50 to 53% egg length. After transplantation within this region, clones were detected in the larval lymph glands. Labeled hemocytes are released by the lymph glands not before the late third larval instar. The anlage of these lymph gland-derived hemocytes is not determined at the blastoderm stage, as indicated by the overlap of clones with other tissues. Our analyses reveal that the hemocytes of pupae and adult flies consist of a mixture of embryonic hemocytes and lymph gland-derived hemocytes, originating from two distinct anlagen that are determined at different stages of development.
Similar articles
- Larval and imaginal pathways in early development of Drosophila.
Harbecke R, Meise M, Holz A, Klapper R, Naffin E, Nordhoff V, Janning W. Harbecke R, et al. Int J Dev Biol. 1996 Feb;40(1):197-204. Int J Dev Biol. 1996. PMID: 8735929 Review. - Postembryonic hematopoiesis in Drosophila.
Lanot R, Zachary D, Holder F, Meister M. Lanot R, et al. Dev Biol. 2001 Feb 15;230(2):243-57. doi: 10.1006/dbio.2000.0123. Dev Biol. 2001. PMID: 11161576 - The Drosophila lymph gland as a developmental model of hematopoiesis.
Jung SH, Evans CJ, Uemura C, Banerjee U. Jung SH, et al. Development. 2005 Jun;132(11):2521-33. doi: 10.1242/dev.01837. Epub 2005 Apr 27. Development. 2005. PMID: 15857916 - Drosophila haematopoiesis.
Crozatier M, Meister M. Crozatier M, et al. Cell Microbiol. 2007 May;9(5):1117-26. doi: 10.1111/j.1462-5822.2007.00930.x. Epub 2007 Mar 29. Cell Microbiol. 2007. PMID: 17394559 Review.
Cited by
- The NF-κB Factor Relish maintains blood progenitor homeostasis in the developing Drosophila lymph gland.
Ramesh P, Tiwari SK, Kaizer M, Jangra D, Ghosh K, Mandal S, Mandal L. Ramesh P, et al. PLoS Genet. 2024 Sep 9;20(9):e1011403. doi: 10.1371/journal.pgen.1011403. eCollection 2024 Sep. PLoS Genet. 2024. PMID: 39250509 Free PMC article. - Molecular Mechanisms of Drosophila Hematopoiesis.
Sinenko SA. Sinenko SA. Acta Naturae. 2024 Apr-Jun;16(2):4-21. doi: 10.32607/actanaturae.27410. Acta Naturae. 2024. PMID: 39188265 Free PMC article. - The Drosophila hematopoietic niche assembles through collective cell migration controlled by neighbor tissues and Slit-Robo signaling.
Nelson KA, Lenhart KF, Anllo L, DiNardo S. Nelson KA, et al. bioRxiv [Preprint]. 2024 Oct 15:2024.06.21.600069. doi: 10.1101/2024.06.21.600069. bioRxiv. 2024. PMID: 38979182 Free PMC article. Preprint. - An atlas of spider development at single-cell resolution provides new insights into arthropod embryogenesis.
Leite DJ, Schönauer A, Blakeley G, Harper A, Garcia-Castro H, Baudouin-Gonzalez L, Wang R, Sarkis N, Nikola AG, Koka VSP, Kenny NJ, Turetzek N, Pechmann M, Solana J, McGregor AP. Leite DJ, et al. Evodevo. 2024 May 10;15(1):5. doi: 10.1186/s13227-024-00224-4. Evodevo. 2024. PMID: 38730509 Free PMC article. - Mitochondrial perturbation in immune cells enhances cell-mediated innate immunity in Drosophila.
Vesala L, Basikhina Y, Tuomela T, Nurminen A, Siukola E, Vale PF, Salminen TS. Vesala L, et al. BMC Biol. 2024 Mar 13;22(1):60. doi: 10.1186/s12915-024-01858-5. BMC Biol. 2024. PMID: 38475850 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials