Similarities and differences in CD4+ and CD8+ effector and memory T cell generation - PubMed (original) (raw)
Review
doi: 10.1038/ni969.
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- PMID: 12942084
- DOI: 10.1038/ni969
Review
Similarities and differences in CD4+ and CD8+ effector and memory T cell generation
Robert A Seder et al. Nat Immunol. 2003 Sep.
Abstract
Naive CD4+ and CD8+ T cells undergo unique developmental programs after activation, resulting in the generation of effector and long-lived memory T cells. Recent evidence indicates that both cell-intrinsic and cell-extrinsic factors regulate memory T cell differentiation. This review compares and contrasts how naive CD4+ and CD8+ T cells make the transition to effector and/or memory cells and discusses the implications of these findings for vaccine development.
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