c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis - PubMed (original) (raw)
. 2003 Aug 28;22(36):5707-11.
doi: 10.1038/sj.onc.1206800.
Affiliations
- PMID: 12944920
- DOI: 10.1038/sj.onc.1206800
c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis
Satoshi Kanazawa et al. Oncogene. 2003.
Abstract
c-Myc promotes cellular proliferation, sensitizes cells to apoptosis and prevents differentiation. It binds cyclin T1 structurally and functionally from the positive transcription elongation factor b (P-TEFb). The cyclin-dependent kinase 9 (Cdk9) in P-TEFb then phosporylates the C-terminal domain of RNA polymerase II, which is required for the transition from initiation to elongation of eukaryotic transcription. Inhibiting P-TEFb blocks the transcription of its target genes as well as cellular proliferation and apoptosis induced by c-Myc.
Similar articles
- siRNA depletion of 7SK snRNA induces apoptosis but does not affect expression of the HIV-1 LTR or P-TEFb-dependent cellular genes.
Haaland RE, Herrmann CH, Rice AP. Haaland RE, et al. J Cell Physiol. 2005 Dec;205(3):463-70. doi: 10.1002/jcp.20528. J Cell Physiol. 2005. PMID: 16152622 - RNA-driven cyclin-dependent kinase regulation: when CDK9/cyclin T subunits of P-TEFb meet their ribonucleoprotein partners.
Michels AA, Bensaude O. Michels AA, et al. Biotechnol J. 2008 Aug;3(8):1022-32. doi: 10.1002/biot.200800104. Biotechnol J. 2008. PMID: 18655042 Review. - Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4.
Yang Z, Yik JH, Chen R, He N, Jang MK, Ozato K, Zhou Q. Yang Z, et al. Mol Cell. 2005 Aug 19;19(4):535-45. doi: 10.1016/j.molcel.2005.06.029. Mol Cell. 2005. PMID: 16109377 - Cellular control of gene expression by T-type cyclin/CDK9 complexes.
Garriga J, Graña X. Garriga J, et al. Gene. 2004 Aug 4;337:15-23. doi: 10.1016/j.gene.2004.05.007. Gene. 2004. PMID: 15276198 Review. - A model of repression: CTD analogs and PIE-1 inhibit transcriptional elongation by P-TEFb.
Zhang F, Barboric M, Blackwell TK, Peterlin BM. Zhang F, et al. Genes Dev. 2003 Mar 15;17(6):748-58. doi: 10.1101/gad.1068203. Genes Dev. 2003. PMID: 12651893 Free PMC article.
Cited by
- MicroRNA-34a modulates c-Myc transcriptional complexes to suppress malignancy in human prostate cancer cells.
Yamamura S, Saini S, Majid S, Hirata H, Ueno K, Deng G, Dahiya R. Yamamura S, et al. PLoS One. 2012;7(1):e29722. doi: 10.1371/journal.pone.0029722. Epub 2012 Jan 3. PLoS One. 2012. PMID: 22235332 Free PMC article. - LARP7 is a potential tumor suppressor gene in gastric cancer.
Cheng Y, Jin Z, Agarwal R, Ma K, Yang J, Ibrahim S, Olaru AV, David S, Ashktorab H, Smoot DT, Duncan MD, Hutcheon DF, Abraham JM, Meltzer SJ, Mori Y. Cheng Y, et al. Lab Invest. 2012 Jul;92(7):1013-9. doi: 10.1038/labinvest.2012.59. Epub 2012 Apr 9. Lab Invest. 2012. PMID: 22488152 Free PMC article. - SKIP interacts with c-Myc and Menin to promote HIV-1 Tat transactivation.
Brès V, Yoshida T, Pickle L, Jones KA. Brès V, et al. Mol Cell. 2009 Oct 9;36(1):75-87. doi: 10.1016/j.molcel.2009.08.015. Mol Cell. 2009. PMID: 19818711 Free PMC article. - P-TEFb- the final frontier.
Kohoutek J. Kohoutek J. Cell Div. 2009 Sep 2;4:19. doi: 10.1186/1747-1028-4-19. Cell Div. 2009. PMID: 19723344 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous