Ghrelin-induced feeding is dependent on nitric oxide - PubMed (original) (raw)
Ghrelin-induced feeding is dependent on nitric oxide
F Spencer Gaskin et al. Peptides. 2003 Jun.
Abstract
Ghrelin is a newly discovered gastric peptide, which has orexigenic effects. Ghrelin is the endogenous ligand for the growth hormone secretagogue receptor and stimulates growth hormone and gastrointestinal motility. We have previously shown that nitric oxide (NO) plays an important role as a mediator of feeding induced by a variety of neuropeptides. This raises the question of whether ghrelin's effects are NO dependent. Here, we first determined that intracerebroventricular administration of 100 ng of ghrelin significantly increased food intake in satiated mice. We next examined the effects of N(omega)-nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase inhibitor, on ghrelin-induced increase in food intake. A subthreshold dose (12.5mg/kg; SC) of L-NAME significantly blocked the ghrelin-induced increase in food intake. Ghrelin administration increased the levels of nitric oxide synthase in the hypothalamus. This supports the hypothesis that nitric oxide is a central regulator of food consumption.
Similar articles
- Orexin-A-induced feeding is dependent on nitric oxide.
Farr SA, Banks WA, Kumar VB, Morley JE. Farr SA, et al. Peptides. 2005 May;26(5):759-65. doi: 10.1016/j.peptides.2004.12.004. Epub 2005 Jan 12. Peptides. 2005. PMID: 15808906 - Ghrelin protects against ethanol-induced gastric ulcers in rats: studies on the mechanisms of action.
Sibilia V, Rindi G, Pagani F, Rapetti D, Locatelli V, Torsello A, Campanini N, Deghenghi R, Netti C. Sibilia V, et al. Endocrinology. 2003 Jan;144(1):353-9. doi: 10.1210/en.2002-220756. Endocrinology. 2003. PMID: 12488364 - Ghrelin-induced gastroprotection against ischemia-reperfusion injury involves an activation of sensory afferent nerves and hyperemia mediated by nitric oxide.
Konturek PC, Brzozowski T, Walter B, Burnat G, Hess T, Hahn EG, Konturek SJ. Konturek PC, et al. Eur J Pharmacol. 2006 Apr 24;536(1-2):171-81. doi: 10.1016/j.ejphar.2006.02.032. Epub 2006 Feb 28. Eur J Pharmacol. 2006. PMID: 16581065 - [Ghrelin-neuropeptide Y axis in the control of feeding and gastrointestinal motility].
Inui A. Inui A. Nihon Yakurigaku Zasshi. 2006 Feb;127(2):83-7. doi: 10.1254/fpj.127.83. Nihon Yakurigaku Zasshi. 2006. PMID: 16595977 Review. Japanese. No abstract available. - Nitric oxide and tubulointerstitial nephritides.
Mattana J, Adamidis A, Singhal PC. Mattana J, et al. Semin Nephrol. 2004 Jul;24(4):345-53. doi: 10.1016/j.semnephrol.2004.04.006. Semin Nephrol. 2004. PMID: 15252774 Review.
Cited by
- Effects of triglycerides, obesity, and starvation on ghrelin transport across the blood-brain barrier.
Banks WA, Burney BO, Robinson SM. Banks WA, et al. Peptides. 2008 Nov;29(11):2061-5. doi: 10.1016/j.peptides.2008.07.001. Epub 2008 Jul 17. Peptides. 2008. PMID: 18682266 Free PMC article. - Effects of "Bioactive" amino acids leucine, glutamate, arginine and tryptophan on feed intake and mRNA expression of relative neuropeptides in broiler chicks.
Wang S, Khondowe P, Chen S, Yu J, Shu G, Zhu X, Wang L, Gao P, Xi Q, Zhang Y, Jiang Q. Wang S, et al. J Anim Sci Biotechnol. 2012 Aug 24;3(1):27. doi: 10.1186/2049-1891-3-27. J Anim Sci Biotechnol. 2012. PMID: 22958345 Free PMC article. - Effects of Long-term Graded L-arginine Supply on Growth Development, Egg Laying and Egg Quality in Four Genetically Diverse Purebred Layer Lines.
Lieboldt MA, Halle I, Frahm J, Schrader L, Weigend S, Preisinger R, Dänicke S. Lieboldt MA, et al. J Poult Sci. 2016 Jan 25;53(1):8-21. doi: 10.2141/jpsa.0150067. J Poult Sci. 2016. PMID: 32908358 Free PMC article. - Comparison of Antioxidant Capacity and Muscle Amino Acid and Fatty Acid Composition of Nervous and Calm Hu Sheep.
Zhang J, Zhang Y, Wang J, Jin H, Qian S, Chen P, Wang M, Chen N, Ding L. Zhang J, et al. Antioxidants (Basel). 2023 Feb 11;12(2):459. doi: 10.3390/antiox12020459. Antioxidants (Basel). 2023. PMID: 36830017 Free PMC article. - Integrating GHS into the Ghrelin System.
Veldhuis JD, Bowers CY. Veldhuis JD, et al. Int J Pept. 2010;2010:879503. doi: 10.1155/2010/879503. Epub 2010 Mar 18. Int J Pept. 2010. PMID: 20798846 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources