Reassessing the function of immune-complex retention by follicular dendritic cells - PubMed (original) (raw)

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doi: 10.1038/nri1178.

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• PMID: 12949499
• DOI: 10.1038/nri1178

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Reassessing the function of immune-complex retention by follicular dendritic cells

Ann M Haberman et al. Nat Rev Immunol. 2003 Sep.

Abstract

The close association of follicular dendritic cells (FDCs) and germinal-centre B cells has fostered the idea that B-cell recognition of retained antigen that is presented on the surface of FDCs is important for affinity maturation and memory B-cell development. We argue that the retention of immune complexes is not required for germinal-centre development, affinity maturation and memory B-cell maintenance. Instead, it is probable that FDCs support B-cell proliferation and differentiation in a non-specific manner. Other potential roles of immune complexes retained by FDCs are discussed.

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