Membrane dynamics, cholesterol homeostasis, and Alzheimer's disease - PubMed (original) (raw)

Review

. 2003 Nov;44(11):2019-29.

doi: 10.1194/jlr.R300010-JLR200. Epub 2003 Sep 1.

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• PMID: 12951356
• DOI: 10.1194/jlr.R300010-JLR200

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Review

Membrane dynamics, cholesterol homeostasis, and Alzheimer's disease

Neelima B Chauhan. J Lipid Res. 2003 Nov.

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Abstract

Alzheimer's disease (AD) is characterized by the deposition of beta-amyloid (A beta) plaques derived from the amyloidogenic processing; of a transmembrane protein called beta-amyloid precursor protein (APP). In addition to the known genetic/sporadic factors that promote the formation of A beta, the composition and structural dynamics of the membrane are also thought to play a significant role in the amyloidogenic processing of APP that promotes seeding of A beta. This minireview reinforces the roles played by membrane dynamics, membrane microdomains, and cholesterol homeostasis in relation to amyloidogenesis, and reviews current strategies of lowering cholesterol in treating AD.

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