Genomic instability--the engine of tumorigenesis? - PubMed (original) (raw)
Review
doi: 10.1038/nrc1170.
Affiliations
- PMID: 12951589
- DOI: 10.1038/nrc1170
Review
Genomic instability--the engine of tumorigenesis?
Oliver M Sieber et al. Nat Rev Cancer. 2003 Sep.
Abstract
Human cancers harbour numerous mutations and it has been proposed that these result from some form of inherent genomic instability. Some cancers have proven genomic instability or features that are indicative of this. Inherited cancer syndromes exist that are caused by deficient DNA repair or chromosomal integrity. By contrast, theoretical analysis and experimental data from sporadic colorectal tumours provide little general evidence of genomic instability in early lesions. These apparently conflicting data raise the question of whether or not genomic instability is necessary for driving tumour growth, and whether or not it is the usual initiating event in tumorigenesis.
Similar articles
- Genomic stability and tumorigenesis.
Sieber O, Heinimann K, Tomlinson I. Sieber O, et al. Semin Cancer Biol. 2005 Feb;15(1):61-6. doi: 10.1016/j.semcancer.2004.09.005. Semin Cancer Biol. 2005. PMID: 15613289 Review. - Can chromosomal instability initiate tumorigenesis?
Michor F, Iwasa Y, Vogelstein B, Lengauer C, Nowak MA. Michor F, et al. Semin Cancer Biol. 2005 Feb;15(1):43-9. doi: 10.1016/j.semcancer.2004.09.007. Semin Cancer Biol. 2005. PMID: 15613287 Review. - Genomic instability en route to and from cancer stem cells.
Li L, Borodyansky L, Yang Y. Li L, et al. Cell Cycle. 2009 Apr 1;8(7):1000-2. doi: 10.4161/cc.8.7.8041. Epub 2009 Apr 11. Cell Cycle. 2009. PMID: 19270518 - Chromosomal instability and p53 inactivation are required for genesis of glioblastoma but not for colorectal cancer in patients with germline mismatch repair gene mutation.
Leung SY, Yuen ST, Chan TL, Chan AS, Ho JW, Kwan K, Fan YW, Hung KN, Chung LP, Wyllie AH. Leung SY, et al. Oncogene. 2000 Aug 17;19(35):4079-83. doi: 10.1038/sj.onc.1203740. Oncogene. 2000. PMID: 10962567 - Molecular cytogenetic evidence for multistep tumorigenesis: implications for risk assessment and early detection.
Sen S, Hopwood V. Sen S, et al. Cancer Biomark. 2010;9(1-6):113-32. doi: 10.3233/CBM-2011-0171. Cancer Biomark. 2010. PMID: 22112472 Review.
Cited by
- A deep-learning-based genomic status estimating framework for homologous recombination deficiency detection from low-pass whole genome sequencing.
Liu Y, Bi X, Leng Y, Chen D, Wang J, Ma Y, Zhang MZ, Han BW, Li Y. Liu Y, et al. Heliyon. 2024 Feb 9;10(4):e26121. doi: 10.1016/j.heliyon.2024.e26121. eCollection 2024 Feb 29. Heliyon. 2024. PMID: 38404843 Free PMC article. - Integrated approach to reducing polypharmacy in older people: exploring the role of oxidative stress and antioxidant potential therapy.
Rojas-Solé C, Pinilla-González V, Lillo-Moya J, González-Fernández T, Saso L, Rodrigo R. Rojas-Solé C, et al. Redox Rep. 2024 Dec;29(1):2289740. doi: 10.1080/13510002.2023.2289740. Epub 2023 Dec 18. Redox Rep. 2024. PMID: 38108325 Free PMC article. Review. - Combination Treatment Strategies to Overcome PARP Inhibitor Resistance.
Soung YH, Chung J. Soung YH, et al. Biomolecules. 2023 Oct 3;13(10):1480. doi: 10.3390/biom13101480. Biomolecules. 2023. PMID: 37892162 Free PMC article. Review. - Genomic Instability Evolutionary Footprints on Human Health: Driving Forces or Side Effects?
Veschetti L, Treccani M, De Tomi E, Malerba G. Veschetti L, et al. Int J Mol Sci. 2023 Jul 14;24(14):11437. doi: 10.3390/ijms241411437. Int J Mol Sci. 2023. PMID: 37511197 Free PMC article. Review. - Targeting DNA repair for cancer treatment: Lessons from PARP inhibitor trials.
Nambiar DK, Mishra D, Singh RP. Nambiar DK, et al. Oncol Res. 2023 Jun 27;31(4):405-421. doi: 10.32604/or.2023.028310. eCollection 2023. Oncol Res. 2023. PMID: 37415740 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources