Transplanted adult hematopoietic stems cells differentiate into functional endothelial cells - PubMed (original) (raw)
. 2004 Jan 1;103(1):13-9.
doi: 10.1182/blood-2003-05-1684. Epub 2003 Sep 4.
Affiliations
- PMID: 12958072
- DOI: 10.1182/blood-2003-05-1684
Free article
Transplanted adult hematopoietic stems cells differentiate into functional endothelial cells
Alexis S Bailey et al. Blood. 2004.
Free article
Abstract
During early embryogenesis, blood vessels and hematopoietic cells arise from a common precursor cell, the hemangioblast. Recent studies have identified endothelial progenitor cells in the peripheral blood, and there is accumulating evidence that a subset of these cells is derived from precursors in the bone marrow. Here we show that adult bone marrow-derived, phenotypically defined hematopoietic stem cells (c-kit+, Sca-1+, lineage-) give rise to functional endothelial cells. With the exception of the brain, donor-derived cells are rapidly integrated into blood vessels. Durably engrafted endothelial cells express CD31, produce von Willebrand factor, and take up low-density lipoprotein. Analysis of DNA content indicates that donor-derived endothelial cells are not the products of cell fusion. Self-renewal of stem cells with hematopoietic and endothelial cell potential was revealed by serial transplantation studies. The clonal origin of both hematopoietic and endothelial cell outcomes was established by the transfer of a single cell. These results suggest that adult bone marrow-derived hematopoietic stem cells may serve as a reservoir for endothelial cell progenitors.
Similar articles
- Hematopoietic origin of microglial and perivascular cells in brain.
Hess DC, Abe T, Hill WD, Studdard AM, Carothers J, Masuya M, Fleming PA, Drake CJ, Ogawa M. Hess DC, et al. Exp Neurol. 2004 Apr;186(2):134-44. doi: 10.1016/j.expneurol.2003.11.005. Exp Neurol. 2004. PMID: 15026252 - Hematopoietic stem cells and endothelial cell precursors express Tie-2, CD31 and CD45.
Shaw JP, Basch R, Shamamian P. Shaw JP, et al. Blood Cells Mol Dis. 2004 Jan-Feb;32(1):168-75. doi: 10.1016/j.bcmd.2003.10.003. Blood Cells Mol Dis. 2004. PMID: 14757432 - Myeloid lineage progenitors give rise to vascular endothelium.
Bailey AS, Willenbring H, Jiang S, Anderson DA, Schroeder DA, Wong MH, Grompe M, Fleming WH. Bailey AS, et al. Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13156-61. doi: 10.1073/pnas.0604203103. Epub 2006 Aug 18. Proc Natl Acad Sci U S A. 2006. PMID: 16920790 Free PMC article. - Origin of hematopoietic progenitors during embryogenesis.
Ogawa M, Fraser S, Fujimoto T, Endoh M, Nishikawa S, Nishikawa SI. Ogawa M, et al. Int Rev Immunol. 2001 Feb;20(1):21-44. doi: 10.3109/08830180109056721. Int Rev Immunol. 2001. PMID: 11342296 Review. - Converging roads: evidence for an adult hemangioblast.
Bailey AS, Fleming WH. Bailey AS, et al. Exp Hematol. 2003 Nov;31(11):987-93. doi: 10.1016/j.exphem.2003.07.001. Exp Hematol. 2003. PMID: 14585360 Review.
Cited by
- In Silico Evaluation of Coding and Non-Coding nsSNPs in the Thrombopoietin Receptor (MPL) Proto-Oncogene: Assessing Their Influence on Protein Stability, Structure, and Function.
Al-Nakhle HH, Yagoub HS, Anbarkhan SH, Alamri GA, Alsubaie NM. Al-Nakhle HH, et al. Curr Issues Mol Biol. 2023 Nov 23;45(12):9390-9412. doi: 10.3390/cimb45120589. Curr Issues Mol Biol. 2023. PMID: 38132435 Free PMC article. - Endothelial progenitor cells in the host defense response.
Shi X, Seidle KA, Simms KJ, Dong F, Chilian WM, Zhang P. Shi X, et al. Pharmacol Ther. 2023 Jan;241:108315. doi: 10.1016/j.pharmthera.2022.108315. Epub 2022 Nov 24. Pharmacol Ther. 2023. PMID: 36436689 Free PMC article. Review. - Cells expressing early cardiac markers reside in the bone marrow and are mobilized into the peripheral blood after myocardial infarction.
Kucia M, Dawn B, Hunt G, Guo Y, Wysoczynski M, Majka M, Ratajczak J, Rezzoug F, Ildstad ST, Bolli R, Ratajczak MZ. Kucia M, et al. Circ Res. 2004 Dec 10;95(12):1191-9. doi: 10.1161/01.RES.0000150856.47324.5b. Epub 2004 Nov 18. Circ Res. 2004. PMID: 15550692 Free PMC article. - Bone marrow microenvironment and tumor progression.
Chantrain CF, Feron O, Marbaix E, DeClerck YA. Chantrain CF, et al. Cancer Microenviron. 2008 Dec;1(1):23-35. doi: 10.1007/s12307-008-0010-7. Epub 2008 May 7. Cancer Microenviron. 2008. PMID: 19308682 Free PMC article. - Hematopoietic stem cells in neonates: any differences between very preterm and term neonates?
Wisgrill L, Schüller S, Bammer M, Berger A, Pollak A, Radke TF, Kögler G, Spittler A, Helmer H, Husslein P, Gortner L. Wisgrill L, et al. PLoS One. 2014 Sep 2;9(9):e106717. doi: 10.1371/journal.pone.0106717. eCollection 2014. PLoS One. 2014. PMID: 25181353 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials