A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling - PubMed (original) (raw)
Review
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling
Michael T Veeman et al. Dev Cell. 2003 Sep.
Free article
Abstract
More is becoming known about so-called noncanonical Wnt pathways that signal independently of beta-catenin. Here we review recent developments in both the functions and mechanisms of noncanonical Wnt signaling. We also discuss some unresolved and vexing questions. How many noncanonical Wnt pathways are there? How extensive are the parallels between Drosophila planar polarization and vertebrate convergence and extension? Last, we will outline some challenges and difficulties we foresee for this exciting but still very young field.
Similar articles
- Similarities between the Hedgehog and Wnt signaling pathways.
Kalderon D. Kalderon D. Trends Cell Biol. 2002 Nov;12(11):523-31. doi: 10.1016/s0962-8924(02)02388-7. Trends Cell Biol. 2002. PMID: 12446114 Review. - New steps in the Wnt/beta-catenin signal transduction pathway.
Sakanaka C, Sun TQ, Williams LT. Sakanaka C, et al. Recent Prog Horm Res. 2000;55:225-36. Recent Prog Horm Res. 2000. PMID: 11036939 Review. - Beta-catenin: a common target for the regulation of cell adhesion by Wnt-1 and Src signaling pathways.
Hinck L, Näthke IS, Papkoff J, Nelson WJ. Hinck L, et al. Trends Biochem Sci. 1994 Dec;19(12):538-42. doi: 10.1016/0968-0004(94)90057-4. Trends Biochem Sci. 1994. PMID: 7846766 Review. - Identification of a mouse homolog of the human BTEB2 transcription factor as a beta-catenin-independent Wnt-1-responsive gene.
Ziemer LT, Pennica D, Levine AJ. Ziemer LT, et al. Mol Cell Biol. 2001 Jan;21(2):562-74. doi: 10.1128/MCB.21.2.562-574.2001. Mol Cell Biol. 2001. PMID: 11134343 Free PMC article. - You Wnt some, you lose some: oncogenes in the Wnt signaling pathway.
van Es JH, Barker N, Clevers H. van Es JH, et al. Curr Opin Genet Dev. 2003 Feb;13(1):28-33. doi: 10.1016/s0959-437x(02)00012-6. Curr Opin Genet Dev. 2003. PMID: 12573432 Review.
Cited by
- Planar cell polarity signaling: coordination of cellular orientation across tissues.
Singh J, Mlodzik M. Singh J, et al. Wiley Interdiscip Rev Dev Biol. 2012 Jul-Aug;1(4):479-99. doi: 10.1002/wdev.32. Wiley Interdiscip Rev Dev Biol. 2012. PMID: 23066429 Free PMC article. Review. - WNT5A-RHOA Signaling Is a Driver of Tumorigenesis and Represents a Therapeutically Actionable Vulnerability in Small Cell Lung Cancer.
Kim KB, Kim DW, Kim Y, Tang J, Kirk N, Gan Y, Kim B, Fang B, Park JL, Zheng Y, Park KS. Kim KB, et al. Cancer Res. 2022 Nov 15;82(22):4219-4233. doi: 10.1158/0008-5472.CAN-22-1170. Cancer Res. 2022. PMID: 36102736 Free PMC article. - Spatial gene expression profile of Wnt-signaling components in the murine enteric nervous system.
Scharr M, Hirt B, Neckel PH. Scharr M, et al. Front Immunol. 2024 Jan 18;15:1302488. doi: 10.3389/fimmu.2024.1302488. eCollection 2024. Front Immunol. 2024. PMID: 38322254 Free PMC article. - The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-γ in colitis.
Sato A, Kayama H, Shojima K, Matsumoto S, Koyama H, Minami Y, Nojima S, Morii E, Honda H, Takeda K, Kikuchi A. Sato A, et al. Sci Rep. 2015 Jun 1;5:10536. doi: 10.1038/srep10536. Sci Rep. 2015. PMID: 26030277 Free PMC article. - Keeping the balance between proliferation and differentiation: the primary cilium.
Irigoín F, Badano JL. Irigoín F, et al. Curr Genomics. 2011 Jun;12(4):285-97. doi: 10.2174/138920211795860134. Curr Genomics. 2011. PMID: 22131874 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases