LAT regulates gammadelta T cell homeostasis and differentiation - PubMed (original) (raw)
. 2003 Oct;4(10):999-1008.
doi: 10.1038/ni977. Epub 2003 Sep 14.
Affiliations
- PMID: 12970761
- DOI: 10.1038/ni977
LAT regulates gammadelta T cell homeostasis and differentiation
Selene Nuñez-Cruz et al. Nat Immunol. 2003 Oct.
Abstract
LAT (linker for activation of T cells) is essential for T cell receptor signaling. Mice homozygous for a mutation of the three C-terminal LAT tyrosine residues showed a block in alphabeta T cell development and a partially impaired gammadelta T cell development. Without intentional immunization, they accumulated gammadelta T cells in the spleen and lymph nodes that chronically produced T helper type 2 cytokines in large amounts, and caused the maturation of plasma cells secreting immunoglobulin E (IgE) and IgG1. These effects are very similar to that triggered in the alphabeta lineage by a mutation involving a distinct LAT tyrosine. Thus, LAT is an essential regulator of T cell homeostasis and terminal differentiation.
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