Epithelial tube morphogenesis during Drosophila tracheal development requires Piopio, a luminal ZP protein - PubMed (original) (raw)
. 2003 Oct;5(10):895-901.
doi: 10.1038/ncb1049. Epub 2003 Sep 14.
Affiliations
- PMID: 12973360
- DOI: 10.1038/ncb1049
Epithelial tube morphogenesis during Drosophila tracheal development requires Piopio, a luminal ZP protein
Anna Jaźwińska et al. Nat Cell Biol. 2003 Oct.
Abstract
The formation of branched epithelial networks is fundamental to the development of many organs, such as the lung, the kidney or the vasculature. Little is known about the mechanisms that control cell rearrangements during tubulogenesis and regulate the size of individual tubes. Recent studies indicate that whereas the basal surface of tube cells interacts with the surrounding tissues and helps to shape the ramification pattern of tubular organs, the apical surface has an important role in the regulation of tube diameter and tube growth. Here we report that two proteins, Piopio (Pio) and Dumpy (Dp), containing a zona pellucida (ZP) domain are essential for the generation of the interconnected tracheal network in Drosophila melanogaster. Pio is secreted apically, accumulates in the tracheal lumen and possibly interacts with Dp through the ZP domains. In the absence of Pio and Dp, multicellular tubes do not rearrange through cell elongation and cell intercalation to form narrow tubes with autocellular junctions; instead they are transformed into multicellular cysts, which leads to a severe disruption of the branched pattern. We propose that an extracellular matrix containing Pio and Dp provides a structural network in the luminal space, around which cell rearrangements can take place in an ordered fashion without losing interconnections. Our results suggest that a similar structural role might be attributed to other ZP-domain proteins in the formation of different branched organs.
Similar articles
- The proteolysis of ZP proteins is essential to control cell membrane structure and integrity of developing tracheal tubes in Drosophila.
Drees L, Schneider S, Riedel D, Schuh R, Behr M. Drees L, et al. Elife. 2023 Oct 24;12:e91079. doi: 10.7554/eLife.91079. Elife. 2023. PMID: 37872795 Free PMC article. - Papillote and Piopio: Drosophila ZP-domain proteins required for cell adhesion to the apical extracellular matrix and microtubule organization.
Bökel C, Prokop A, Brown NH. Bökel C, et al. J Cell Sci. 2005 Feb 1;118(Pt 3):633-42. doi: 10.1242/jcs.01619. Epub 2005 Jan 18. J Cell Sci. 2005. PMID: 15657084 - Genetic control of cell intercalation during tracheal morphogenesis in Drosophila.
Ribeiro C, Neumann M, Affolter M. Ribeiro C, et al. Curr Biol. 2004 Dec 29;14(24):2197-207. doi: 10.1016/j.cub.2004.11.056. Curr Biol. 2004. PMID: 15620646 - Tubulogenesis: zipping up your fly.
Paul SM, Beitel GJ. Paul SM, et al. Curr Biol. 2005 Jan 26;15(2):R70-2. doi: 10.1016/j.cub.2004.12.060. Curr Biol. 2005. PMID: 15668162 Review. - From fate to function: the Drosophila trachea and salivary gland as models for tubulogenesis.
Kerman BE, Cheshire AM, Andrew DJ. Kerman BE, et al. Differentiation. 2006 Sep;74(7):326-48. doi: 10.1111/j.1432-0436.2006.00095.x. Differentiation. 2006. PMID: 16916373 Free PMC article. Review.
Cited by
- Apical cell expansion maintained by Dusky-like establishes a scaffold for corneal lens morphogenesis.
Ghosh N, Treisman JE. Ghosh N, et al. Sci Adv. 2024 Aug 23;10(34):eado4167. doi: 10.1126/sciadv.ado4167. Epub 2024 Aug 21. Sci Adv. 2024. PMID: 39167639 Free PMC article. - The proteolysis of ZP proteins is essential to control cell membrane structure and integrity of developing tracheal tubes in Drosophila.
Drees L, Schneider S, Riedel D, Schuh R, Behr M. Drees L, et al. Elife. 2023 Oct 24;12:e91079. doi: 10.7554/eLife.91079. Elife. 2023. PMID: 37872795 Free PMC article. - Morphogenetic Roles of Hydrostatic Pressure in Animal Development.
Bagnat M, Daga B, Di Talia S. Bagnat M, et al. Annu Rev Cell Dev Biol. 2022 Oct 6;38:375-394. doi: 10.1146/annurev-cellbio-120320-033250. Epub 2022 Jul 8. Annu Rev Cell Dev Biol. 2022. PMID: 35804476 Free PMC article. Review. - Chitin deacetylases are necessary for insect femur muscle attachment and mobility.
Mun S, Noh MY, Geisbrecht ER, Kramer KJ, Muthukrishnan S, Arakane Y. Mun S, et al. Proc Natl Acad Sci U S A. 2022 Jun 14;119(24):e2120853119. doi: 10.1073/pnas.2120853119. Epub 2022 Jun 8. Proc Natl Acad Sci U S A. 2022. PMID: 35675426 Free PMC article. - A direct-drive GFP reporter for studies of tracheal development in Drosophila.
Lam G, Beebe K, Thummel CS. Lam G, et al. Fly (Austin). 2022 Dec;16(1):105-110. doi: 10.1080/19336934.2022.2030191. Fly (Austin). 2022. PMID: 35094652 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases