A comparative histologic and immunologic study in rabbits of induced hypersensitivity of the serum sickness type - PubMed (original) (raw)

A comparative histologic and immunologic study in rabbits of induced hypersensitivity of the serum sickness type

F G GERMUTH Jr. J Exp Med. 1953.

Abstract

A histologic and quantitative immunologic study was made on a large group of rabbits injected intravenously with a single dose of crystallized bovine albumin and bled and sacrificed at various intervals after injection. Both cardiovascular and renal lesions were encountered in high incidence. The various stages in the development of these lesions were observed from their first appearance until their complete regression. The cardiac, vascular, and renal alterations were morphologically similar to those of rheumatic fever, polyarteritis nodosa, and acute glomerulonephritis, respectively, in man. In addition to those tissue changes ordinarily attributed to hypersensitivity, peculiar granulomatous lesions consisting of epithelioid and foreign body giant cells were encountered in the follicles of the spleen and in the lymph nodes of a large proportion of the animals receiving the antigen. Similar granulomas in the spleen and lymph nodes as well as in other tissues have been described in polyarteritis nodosa. The present experimental demonstration that an epithelioid and giant cell reaction may result from hypersensitivity provides evidence for the allergic origin of those cases of polyarteritis nodosa of unknown etiology containing this type of lesion. In the present study the time of development of the cardiovascular, renal, and granulomatous lesions was determined in relation to the blood clearance of antigen and the time of appearance of circulating antibody. All the tissue lesions developed during the "immune" phase of antigen elimination and regressed after the antigen had been completely eliminated and free antibody had appeared in the circulation. These temporal relationships indicate that the tissue lesions which occur after the intravenous administration of foreign protein are the result of antigen-antibody combination.

PubMed Disclaimer

Similar articles

• The mechanism of action of cortisone in experimental hypersensitivity. II. Hypersensitivity of the serum sickness type.
  GERMUTH FG Jr. GERMUTH FG Jr. J Exp Med. 1953 Jul;98(1):1-12. doi: 10.1084/jem.98.1.1. J Exp Med. 1953. PMID: 13069645 Free PMC article.
• HISTOLOGICAL AND SEROLOGICAL SEQUENCES IN EXPERIMENTAL HYPERSENSITIVITY.
  Hawn CV, Janeway CA. Hawn CV, et al. J Exp Med. 1947 May 31;85(6):571-90. doi: 10.1084/jem.85.6.571. J Exp Med. 1947. PMID: 19871637 Free PMC article.
• Pathology of allergic diseases.
  Schwartz A. Schwartz A. Acta Univ Carol Med Monogr. 1989;129:1-197. Acta Univ Carol Med Monogr. 1989. PMID: 2486027 Review.
• Assessment of the morphology and significance of the lymph nodal and hepatic lesions produced in rats by the feeding of certain mineral oils and waxes. Proceedings of a pathology workshop held at the Fraunhofer Institute of Toxicology and Aerosol Research Hannover, Germany, May 7-9, 2001.
  Carlton WW, Boitnott JK, Dungworth DL, Ernst H, Hayashi Y, Mohr U, Parodi AL, Pattengale PK, Rittinghausen S, Ward JM. Carlton WW, et al. Exp Toxicol Pathol. 2001 Sep;53(4):247-55. doi: 10.1078/0940-2993-00198. Exp Toxicol Pathol. 2001. PMID: 11665848 Review.

Cited by

• Historical milestones in renal pathology.
  Weening JJ, Jennette JC. Weening JJ, et al. Virchows Arch. 2012 Jul;461(1):3-11. doi: 10.1007/s00428-012-1254-7. Epub 2012 Jun 3. Virchows Arch. 2012. PMID: 22661128 Free PMC article. No abstract available.
• Alimentary Granulomata and the Immune Response.
  Slaney G. Slaney G. Postgrad Med J. 1961 May;37(427):276-81. doi: 10.1136/pgmj.37.427.276. Postgrad Med J. 1961. PMID: 21313660 Free PMC article. No abstract available.
• Post-streptococcal acute glomerulonephritis in children: clinical features and pathogenesis.
  Eison TM, Ault BH, Jones DP, Chesney RW, Wyatt RJ. Eison TM, et al. Pediatr Nephrol. 2011 Feb;26(2):165-80. doi: 10.1007/s00467-010-1554-6. Epub 2010 Jul 23. Pediatr Nephrol. 2011. PMID: 20652330 Review.
• The relationships between serum complement activity and the development of allergic lesions in rabbits.
  RHYNE MB, GERMUTH FG Jr. RHYNE MB, et al. J Exp Med. 1961 Nov 1;114(5):633-46. doi: 10.1084/jem.114.5.633. J Exp Med. 1961. PMID: 14491800 Free PMC article.
• Studies in molecular pathology. I. Localization and pathogenic role of heterologous immune complexes.
  MELLORS RC, BRZOSKO WJ. MELLORS RC, et al. J Exp Med. 1962 May 1;115(5):891-902. doi: 10.1084/jem.115.5.891. J Exp Med. 1962. PMID: 14472423 Free PMC article.

References

1. 1. J Exp Med. 1942 Oct 1;76(4):335-48 - PubMed
2. 1. J Exp Med. 1947 May 31;85(6):571-90 - PubMed
3. 1. J Exp Med. 1924 Sep 30;40(4):543-51 - PubMed
4. 1. Am J Pathol. 1946 Jul;22(4):703-35 - PubMed
5. 1. J Exp Med. 1949 May;89(5):555-60 - PubMed

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • Ovid Technologies, Inc.
  • PubMed Central
  • Silverchair Information Systems

• Other Literature Sources

  • The Lens - Patent Citations Database