[A study of the antiarrhythmic mechanism of berberine on delayed activation potassium current by voltage clamp] - PubMed (original) (raw)
. 1992 Oct;20(5):310-2, 325.
[Article in Chinese]
Affiliations
- PMID: 1306830
[A study of the antiarrhythmic mechanism of berberine on delayed activation potassium current by voltage clamp]
[Article in Chinese]
W M Huang. Zhonghua Xin Xue Guan Bing Za Zhi. 1992 Oct.
Abstract
The effects of berberine (0.1-10 mg/L) on delayed activation potassium current (iK) of canine Purkinje fibers were studied with two-microelectrode voltage clamp technique. Berberine (Ber) significantly reduced the amplitude of iK in concentration-dependent manner. When perfused with 10 mg/L Ber, the amplitude of tail current of the Purkinje fibers decreased immediately and the inhibition rate was 73.6 +/- 4.5% (n = 9, P < 0.001). The inhibition effect of berberine on iK may explain its prolongation effect on action potential duration and its antiarrhythmic action.
Similar articles
- Inhibitory effects of berberine on IK1, IK, and HERG channels of cardiac myocytes.
Li BX, Yang BF, Zhou J, Xu CQ, Li YR. Li BX, et al. Acta Pharmacol Sin. 2001 Feb;22(2):125-31. Acta Pharmacol Sin. 2001. PMID: 11741516 - [Effects of benzyltetrahydropalmatine on action potentials of myocardium and transmembrane K+ and Ca2+ currents in Purkinje fibers].
Zeng WZ, Xia GJ, Yao WX, Zong XG, Jiang MX. Zeng WZ, et al. Zhongguo Yao Li Xue Bao. 1990 Jul;11(4):314-7. Zhongguo Yao Li Xue Bao. 1990. PMID: 2104484 Chinese. - Carvedilol and vesnarinone: new antiarrhythmic approach in heart failure therapy.
Cheng JH, Kamiya K, Kodama I. Cheng JH, et al. Acta Pharmacol Sin. 2001 Mar;22(3):193-200. Acta Pharmacol Sin. 2001. PMID: 11742564 Review. - Cardiovascular actions of berberine.
Lau CW, Yao XQ, Chen ZY, Ko WH, Huang Y. Lau CW, et al. Cardiovasc Drug Rev. 2001 Fall;19(3):234-44. doi: 10.1111/j.1527-3466.2001.tb00068.x. Cardiovasc Drug Rev. 2001. PMID: 11607041 Review.
Cited by
- Berberine inhibition of electrogenic ion transport in rat colon.
Taylor CT, Baird AW. Taylor CT, et al. Br J Pharmacol. 1995 Nov;116(6):2667-72. doi: 10.1111/j.1476-5381.1995.tb17224.x. Br J Pharmacol. 1995. PMID: 8590987 Free PMC article. - Berberine inhibits NLRP3 Inflammasome pathway in human triple-negative breast cancer MDA-MB-231 cell.
Yao M, Fan X, Yuan B, Takagi N, Liu S, Han X, Ren J, Liu J. Yao M, et al. BMC Complement Altern Med. 2019 Aug 14;19(1):216. doi: 10.1186/s12906-019-2615-4. BMC Complement Altern Med. 2019. PMID: 31412862 Free PMC article. - Antimicrobial Natural Product Berberine Is Efficacious for the Treatment of Atrial Fibrillation.
Zheng H, Zhu F, Miao P, Mao Z, Redfearn DP, Cao RY. Zheng H, et al. Biomed Res Int. 2017;2017:3146791. doi: 10.1155/2017/3146791. Epub 2017 Dec 17. Biomed Res Int. 2017. PMID: 29392132 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources