Herpesvirus saimiri encodes homologues of G protein-coupled receptors and cyclins - PubMed (original) (raw)
Comparative Study
. 1992 Jan 23;355(6358):362-5.
doi: 10.1038/355362a0.
Affiliations
- PMID: 1309943
- DOI: 10.1038/355362a0
Comparative Study
Herpesvirus saimiri encodes homologues of G protein-coupled receptors and cyclins
J Nicholas et al. Nature. 1992.
Abstract
Herpesvirus saimiri (HVS) is a T-lymphotropic gammaherpesvirus which establishes asymptomatic infections in its natural host the squirrel monkey (Saimiri sciureus), but which causes fatal lymphoproliferative diseases in other New World primates. Sequencing studies show HVS is closely related to the human B-lymphotropic gammaherpesvirus Epstein-Barr virus (EBV). However, despite the general colinearity between the genomes of HVS and EBV, HVS contains genes not found in EBV or in the genomes of any of the other sequenced herpesviruses. We have identified two genes, occurring in a region of divergence between HVS and EBV, that have cellular homologues. One of these, ECRF3, is homologous to the genes encoding the human cytomegalovirus (HCMV) and cellular G protein-coupled receptor family of proteins. The other HVS gene, ECLF2, is homologous to the genes encoding cellular cyclins and to our knowledge is the first reported example of a viral cyclin. The presence of G protein-coupled receptor and cyclin homologues in HVS suggests that these genes may be important in the regulation of viral and cellular processes during productive and/or latent infection of host cells, and in particular may be of relevance in the transformation and rapid proliferation of T cells during HVS infections of hosts susceptible to HVS-induced lymphoproliferative diseases.
Similar articles
- Herpesvirus saimiri.
Fickenscher H, Fleckenstein B. Fickenscher H, et al. Philos Trans R Soc Lond B Biol Sci. 2001 Apr 29;356(1408):545-67. doi: 10.1098/rstb.2000.0780. Philos Trans R Soc Lond B Biol Sci. 2001. PMID: 11313011 Free PMC article. Review. - The DNA sequence of equine herpesvirus 2.
Telford EA, Watson MS, Aird HC, Perry J, Davison AJ. Telford EA, et al. J Mol Biol. 1995 Jun 9;249(3):520-8. doi: 10.1006/jmbi.1995.0314. J Mol Biol. 1995. PMID: 7783207 - Analysis of nucleotide sequence of the rightmost 43 kbp of herpesvirus saimiri (HVS) L-DNA: general conservation of genetic organization between HVS and Epstein-Barr virus.
Nicholas J, Cameron KR, Coleman H, Newman C, Honess RW. Nicholas J, et al. Virology. 1992 May;188(1):296-310. doi: 10.1016/0042-6822(92)90759-i. Virology. 1992. PMID: 1314457 - Human cytomegalovirus encodes three G protein-coupled receptor homologues.
Chee MS, Satchwell SC, Preddie E, Weston KM, Barrell BG. Chee MS, et al. Nature. 1990 Apr 19;344(6268):774-7. doi: 10.1038/344774a0. Nature. 1990. PMID: 2158627 - Herpesvirus saimiri as a model for gammaherpesvirus oncogenesis.
Jung JU, Choi JK, Ensser A, Biesinger B. Jung JU, et al. Semin Cancer Biol. 1999 Jun;9(3):231-9. doi: 10.1006/scbi.1998.0115. Semin Cancer Biol. 1999. PMID: 10343074 Review.
Cited by
- Virologs, viral mimicry, and virocell metabolism: the expanding scale of cellular functions encoded in the complex genomes of giant viruses.
Moniruzzaman M, Erazo Garcia MP, Farzad R, Ha AD, Jivaji A, Karki S, Sheyn U, Stanton J, Minch B, Stephens D, Hancks DC, Rodrigues RAL, Abrahao JS, Vardi A, Aylward FO. Moniruzzaman M, et al. FEMS Microbiol Rev. 2023 Sep 5;47(5):fuad053. doi: 10.1093/femsre/fuad053. FEMS Microbiol Rev. 2023. PMID: 37740576 Free PMC article. - Rat Cytomegalovirus Virion-Associated Proteins R131 and R129 Are Necessary for Infection of Macrophages and Dendritic Cells.
Jones IKA, Haese NN, Gatault P, Streblow ZJ, Andoh TF, Denton M, Streblow CE, Bonin K, Kreklywich CN, Burg JM, Orloff SL, Streblow DN. Jones IKA, et al. Pathogens. 2020 Nov 19;9(11):963. doi: 10.3390/pathogens9110963. Pathogens. 2020. PMID: 33228102 Free PMC article. - Breaking Bad: How Viruses Subvert the Cell Cycle.
Fan Y, Sanyal S, Bruzzone R. Fan Y, et al. Front Cell Infect Microbiol. 2018 Nov 19;8:396. doi: 10.3389/fcimb.2018.00396. eCollection 2018. Front Cell Infect Microbiol. 2018. PMID: 30510918 Free PMC article. Review. - Chemokines encoded by herpesviruses.
Pontejo SM, Murphy PM. Pontejo SM, et al. J Leukoc Biol. 2017 Nov;102(5):1199-1217. doi: 10.1189/jlb.4RU0417-145RR. Epub 2017 Aug 28. J Leukoc Biol. 2017. PMID: 28848041 Free PMC article. Review. - Idiopathic pulmonary fibrosis is strongly associated with productive infection by herpesvirus saimiri.
Folcik VA, Garofalo M, Coleman J, Donegan JJ, Rabbani E, Suster S, Nuovo A, Magro CM, Di Leva G, Nuovo GJ. Folcik VA, et al. Mod Pathol. 2014 Jun;27(6):851-62. doi: 10.1038/modpathol.2013.198. Epub 2013 Nov 15. Mod Pathol. 2014. PMID: 24232864 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources