Alpha-helical coiled-coil stalks in the low-affinity receptor for IgE (Fc epsilon RII/CD23) and related C-type lectins - PubMed (original) (raw)

Alpha-helical coiled-coil stalks in the low-affinity receptor for IgE (Fc epsilon RII/CD23) and related C-type lectins

A J Beavil et al. Proc Natl Acad Sci U S A. 1992.

Abstract

The low-affinity receptor for IgE (Fc epsilon RII/CD23) is a cell surface glycoprotein that plays a role in both cellular immunity and allergic inflammation. Its extracellular IgE-binding domain bears homology to C-type animal lectins, and the protein is, therefore, classified as a member of this superfamily. We predict that this lectin-like domain is separated from the cell membrane by an extensive region of alpha-helical coiled-coil structure, based upon sequence comparisons with tropomyosin, the archetypal alpha-helical coiled-coil structure, and detection of characteristic heptad repeats. Analysis of other receptor protein sequences identified a similar structural motif in other membrane-bound members of the C-type lectin superfamily, including the asialoglycoprotein receptor, the Kupffer cell receptor, and the B-cell differentiation antigen Lyb-2 (CD72). It appears that within the C-type lectin superfamily, there is a subfamily of structurally related membrane-bound receptor proteins that contain alpha-helical coiled-coil stalks of various lengths.

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References

1. 1. J Biol Chem. 1987 Jun 5;262(16):7451-4 - PubMed
2. 1. J Biol Chem. 1987 Mar 5;262(7):3022-9 - PubMed
3. 1. J Biol Chem. 1984 Jan 25;259(2):770-8 - PubMed
4. 1. Biopolymers. 1977 Jun;16(6):1271-97 - PubMed
5. 1. Science. 1991 May 24;252(5009):1162-4 - PubMed

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