Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor - PubMed (original) (raw)

Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor

G R Dressler et al. Proc Natl Acad Sci U S A. 1992.

Abstract

The murine Pax-2 gene contains a protein coding domain homologous to the Drosophila paired-box, first described in certain developmental control genes of the segmentation type. Polyclonal antibodies recognize two Pax-2 proteins that are encoded by differentially spliced mRNAs. The Pax-2 proteins can bind a DNA sequence known to interact with the paired domain of a Drosophila protein. By immunocytochemistry, expression of Pax-2 could be localized to the nuclei of condensing mesenchyme cells and their epithelial derivatives in the developing kidney. Expression is abruptly down-regulated as the tubular epithelium differentiates. High levels of Pax-2 expression could also be detected in the epithelial cells of human Wilms tumors. These data suggest that Pax-2 is a transcription factor active during the mesenchyme-to-epithelium transition in early kidney development and in Wilms tumor.

PubMed Disclaimer

Similar articles

• Comparative in situ hybridization analysis of PAX2, PAX8, and WT1 gene transcription in human fetal kidney and Wilms' tumors.
  Eccles MR, Yun K, Reeve AE, Fidler AE. Eccles MR, et al. Am J Pathol. 1995 Jan;146(1):40-5. Am J Pathol. 1995. PMID: 7856737 Free PMC article.
• Pax-2, kidney development, and oncogenesis.
  Dressler GR. Dressler GR. Med Pediatr Oncol. 1996 Nov;27(5):440-4. doi: 10.1002/(SICI)1096-911X(199611)27:5<440::AID-MPO9>3.0.CO;2-M. Med Pediatr Oncol. 1996. PMID: 8827071 Review.
• Re-expression of the developmental gene Pax-2 during experimental acute tubular necrosis in mice 1.
  Imgrund M, Gröne E, Gröne HJ, Kretzler M, Holzman L, Schlöndorff D, Rothenpieler UW. Imgrund M, et al. Kidney Int. 1999 Oct;56(4):1423-31. doi: 10.1046/j.1523-1755.1999.00663.x. Kidney Int. 1999. PMID: 10504494
• Paired box gene expression in Wilms' tumor.
  Tagge EP, Hanson P, Re GG, Othersen HB Jr, Smith CD, Garvin AJ. Tagge EP, et al. J Pediatr Surg. 1994 Feb;29(2):134-41. doi: 10.1016/0022-3468(94)90308-5. J Pediatr Surg. 1994. PMID: 7909843
• Mechanisms of epithelial development and neoplasia in the metanephric kidney.
  Davies JA, Perera AD, Walker CL. Davies JA, et al. Int J Dev Biol. 1999;43(5):473-8. Int J Dev Biol. 1999. PMID: 10535327 Review.

Cited by

• PAX2 in human kidney malformations and disease.
  Harshman LA, Brophy PD. Harshman LA, et al. Pediatr Nephrol. 2012 Aug;27(8):1265-75. doi: 10.1007/s00467-011-2053-0. Epub 2011 Dec 3. Pediatr Nephrol. 2012. PMID: 22138676 Review.
• CD133+ renal progenitor cells contribute to tumor angiogenesis.
  Bruno S, Bussolati B, Grange C, Collino F, Graziano ME, Ferrando U, Camussi G. Bruno S, et al. Am J Pathol. 2006 Dec;169(6):2223-35. doi: 10.2353/ajpath.2006.060498. Am J Pathol. 2006. PMID: 17148683 Free PMC article.
• PAX2 regulates ADAM10 expression and mediates anchorage-independent cell growth of melanoma cells.
  Lee SB, Doberstein K, Baumgarten P, Wieland A, Ungerer C, Bürger C, Hardt K, Boehncke WH, Pfeilschifter J, Mihic-Probst D, Mittelbronn M, Gutwein P. Lee SB, et al. PLoS One. 2011;6(8):e22312. doi: 10.1371/journal.pone.0022312. Epub 2011 Aug 18. PLoS One. 2011. PMID: 21876729 Free PMC article.
• Expression of cholecystokinin by neurons in mouse spinal dorsal horn.
  Gutierrez-Mecinas M, Bell AM, Shepherd F, Polgár E, Watanabe M, Furuta T, Todd AJ. Gutierrez-Mecinas M, et al. J Comp Neurol. 2019 Aug 1;527(11):1857-1871. doi: 10.1002/cne.24657. Epub 2019 Feb 20. J Comp Neurol. 2019. PMID: 30734936 Free PMC article.
• The PAX2 tanscription factor is expressed in cystic and hyperproliferative dysplastic epithelia in human kidney malformations.
  Winyard PJ, Risdon RA, Sams VR, Dressler GR, Woolf AS. Winyard PJ, et al. J Clin Invest. 1996 Jul 15;98(2):451-9. doi: 10.1172/JCI118811. J Clin Invest. 1996. PMID: 8755656 Free PMC article.

References

1. 1. Dev Biol. 1985 Nov;112(1):213-21 - PubMed
2. 1. Cell. 1988 Nov 4;55(3):531-5 - PubMed
3. 1. Nature. 1984 May 10-16;309(5964):176-8 - PubMed
4. 1. Nucleic Acids Res. 1983 Mar 11;11(5):1475-89 - PubMed
5. 1. Exp Cell Res. 1957 Dec;13(3):575-87 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Europe PubMed Central
  • PubMed Central

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information

• Molecular Biology Databases

  • Mouse Genome Informatics (MGI)