Inhibition of poliovirus RNA synthesis by brefeldin A - PubMed (original) (raw)
Inhibition of poliovirus RNA synthesis by brefeldin A
L A Maynell et al. J Virol. 1992 Apr.
Abstract
Brefeldin A (BFA), a fungal metabolite that blocks transport of newly synthesized proteins from the endoplasmic reticulum, was found to inhibit poliovirus replication 10(5)- to 10(6)-fold. BFA does not inhibit entry of poliovirus into the cell or translation of viral RNA. Poliovirus RNA synthesis, however, is completely inhibited by BFA. A specific class of membranous vesicles, with which the poliovirus replication complex is physically associated, is known to proliferate in poliovirus-infected cells. BFA may inhibit poliovirus replication by preventing the formation of these vesicles.
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References
- Cell. 1989 Mar 10;56(5):801-13 - PubMed
- Proc Natl Acad Sci U S A. 1989 Aug;86(15):5795-9 - PubMed
- J Virol. 1985 Nov;56(2):549-57 - PubMed
- Mol Cell Biol. 1985 Nov;5(11):2913-23 - PubMed
- J Virol. 1987 Apr;61(4):986-91 - PubMed
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