Characterization of dexamethasone-induced reactivation of latent bovine herpesvirus 1 - PubMed (original) (raw)

Characterization of dexamethasone-induced reactivation of latent bovine herpesvirus 1

D Rock et al. J Virol. 1992 Apr.

Abstract

Synchronous reactivation of bovine herpesvirus type 1 in all latently infected rabbits was achieved following a single intravenous dose of dexamethasone. Reactivated latent virus was first present in ocular secretions between 48 and 72 h post-dexamethasone treatment (PT). Cell-free infectious virus, viral-antigen-containing neurons, and pathologic changes were detectable in trigeminal ganglia (TG) by 48 h PT. A shift from the viral transcriptional pattern characteristic of the latent state (latency-related RNA [LR RNA]) to one typical of that seen during acute infection was detected in a small number of neurons in latently infected TG between 15 and 18 h PT, with viral DNA first detectable by in situ hybridization at 18 to 21 h PT. The number of LR RNA-containing neurons in latently infected TG decreased significantly at 24 and 48 h PT but returned to near-normal levels by 72 h PT. Correlation of this decrease with viral reactivation suggests that altered regulation of LR RNA transcription is a significant event in the process of viral reactivation.

PubMed Disclaimer

References

    1. Am J Vet Res. 1978 Sep;39(9):1399-403 - PubMed
    1. Am J Vet Res. 1980 Aug;41(8):1212-3 - PubMed
    1. J Virol. 1990 Mar;64(3):1164-70 - PubMed
    1. J Virol. 1990 Dec;64(12):5730-7 - PubMed
    1. J Virol. 1989 Nov;63(11):4882-9 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources