Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation - PubMed (original) (raw)
Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation
D T Hung et al. J Clin Invest. 1992 Apr.
Abstract
Platelet activation by thrombin is critical for hemostasis and thrombosis. Structure-function studies with a recently cloned platelet thrombin receptor suggest that a hirudin-like domain in the receptor's extracellular amino terminal extension is a thrombin-binding determinant important for receptor activation. We now report that a peptide antiserum to this domain is a potent and specific antagonist of thrombin-induced platelet activation. This study demonstrates that the cloned platelet thrombin receptor is necessary for platelet activation by thrombin, and provides a strategy for developing blocking monoclonal antibodies of potential therapeutic value.
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