Participation of non-zinc finger residues in DNA binding by two nuclear orphan receptors - PubMed (original) (raw)

Comparative Study

. 1992 Apr 3;256(5053):107-10.

doi: 10.1126/science.1314418.

Affiliations

• PMID: 1314418
• DOI: 10.1126/science.1314418

Comparative Study

Participation of non-zinc finger residues in DNA binding by two nuclear orphan receptors

T E Wilson et al. Science. 1992.

Abstract

Steroid-thyroid hormone receptors typically bind as dimers to DNA sequences that contain repeated elements termed half-sites. NGFI-B, an early response protein and orphan member of this receptor superfamily, binds to a DNA sequence that contains only one half-site (5'-AAAGGTCA-3'). A domain separate from the NGFI-B zinc fingers, termed the A box, was identified and is required for recognition of the two adenine-thymidine (A-T) base pairs at the 5' end of the NGFI-B DNA binding element. In addition, a domain downstream of the zinc fingers of the orphan receptor H-2 region II binding protein, termed the T box, determined binding to tandem repeats of the estrogen receptor half-site (5'-AGGTCA-3').

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