Allelotype of non-small cell lung carcinoma--comparison between loss of heterozygosity in squamous cell carcinoma and adenocarcinoma - PubMed (original) (raw)
Comparative Study
. 1992 May 1;52(9):2478-81.
Affiliations
- PMID: 1314694
Comparative Study
Allelotype of non-small cell lung carcinoma--comparison between loss of heterozygosity in squamous cell carcinoma and adenocarcinoma
E Tsuchiya et al. Cancer Res. 1992.
Abstract
We examined loss of heterozygosity (LOH) on all autosomal chromosomes in 53 non-small cell lung carcinomas. Frequent LOH was observed on the long arms of chromosomes 1 (37%), 2 (31%), 5 (30%), 8 (31%), and 13 (32%), and the short arms of chromosomes 3 (54%) and 17 (62%). LOH on chromosomes 3p and 17p was observed in all informative cases of squamous cell carcinoma, but was significantly less frequent in adenocarcinomas (P = 0.003 and 0.001, respectively). Similarly, LOH on chromosome 13q was observed frequently in squamous cell carcinomas (5 of 9 informative cases, or 56%), but in only 5 of 26, or 19%, of adenocarcinomas. In contrast, LOH on chromosome 2q was observed only in adenocarcinomas. In addition, this chromosomal arm was lost more frequently in poorly differentiated, compared to well differentiated adenocarcinomas. Furthermore, a correlation between fractional allelic loss and pathohistological grade was identified. These results implicate the presence of several tumor suppressor genes associated with development and/or progression of non-small cell lung carcinomas.
Similar articles
- Difference of allelotype between squamous cell carcinoma and adenocarcinoma of the lung.
Sato S, Nakamura Y, Tsuchiya E. Sato S, et al. Cancer Res. 1994 Nov 1;54(21):5652-5. Cancer Res. 1994. PMID: 7923212 - Deletion mapping on the short arm of chromosome 3 in squamous cell carcinoma and adenocarcinoma of the lung.
Yokoyama S, Yamakawa K, Tsuchiya E, Murata M, Sakiyama S, Nakamura Y. Yokoyama S, et al. Cancer Res. 1992 Feb 15;52(4):873-7. Cancer Res. 1992. PMID: 1346586 - Loss of heterozygosity (LOH) in non-small cell lung cancer: difference between adenocarcinoma and squamous cell carcinoma.
Yoshino I, Osoegawa A, Yohena T, Kameyama T, Oki E, Oda S, Maehara Y. Yoshino I, et al. Respir Med. 2005 Mar;99(3):308-12. doi: 10.1016/j.rmed.2004.08.008. Respir Med. 2005. PMID: 15733506 - Polygenic resistance to mouse pulmonary adenomas.
Hiai H, Abujiang P, Nishimura M. Hiai H, et al. Exp Lung Res. 2000 Dec;26(8):617-25. doi: 10.1080/01902140150216701. Exp Lung Res. 2000. PMID: 11195459 Review. - Global analysis of chromosome 1 genes among patients with lung adenocarcinoma, squamous carcinoma, large-cell carcinoma, small-cell carcinoma, or non-cancer.
Zhang Y, Wang H, Wang J, Bao L, Wang L, Huo J, Wang X. Zhang Y, et al. Cancer Metastasis Rev. 2015 Jun;34(2):249-64. doi: 10.1007/s10555-015-9558-0. Cancer Metastasis Rev. 2015. PMID: 25937073 Review.
Cited by
- Different subtypes of human lung adenocarcinoma caused by different etiological factors. Evidence from p53 mutational spectra.
Hashimoto T, Tokuchi Y, Hayashi M, Kobayashi Y, Nishida K, Hayashi S, Ishikawa Y, Nakagawa K, Hayashi J, Tsuchiya E. Hashimoto T, et al. Am J Pathol. 2000 Dec;157(6):2133-41. doi: 10.1016/s0002-9440(10)64851-1. Am J Pathol. 2000. PMID: 11106585 Free PMC article. - MYCL genotypes and loss of heterozygosity in non-small-cell lung cancer.
Fong KM, Kida Y, Zimmerman PV, Smith PJ. Fong KM, et al. Br J Cancer. 1996 Dec;74(12):1975-8. doi: 10.1038/bjc.1996.662. Br J Cancer. 1996. PMID: 8980399 Free PMC article. - Aberrations of the APC gene in primary breast carcinoma.
Kashiwaba M, Tamura G, Ishida M. Kashiwaba M, et al. J Cancer Res Clin Oncol. 1994;120(12):727-31. doi: 10.1007/BF01194271. J Cancer Res Clin Oncol. 1994. PMID: 7798298 - Allelic imbalance and instability of microsatellite loci on chromosome 1p in human non-small-cell lung cancer.
Gasparian AV, Laktionov KK, Belialova MS, Pirogova NA, Tatosyan AG, Zborovskaya IB. Gasparian AV, et al. Br J Cancer. 1998 May;77(10):1604-11. doi: 10.1038/bjc.1998.263. Br J Cancer. 1998. PMID: 9635835 Free PMC article. - Loss of heterozygosity analyzed by single nucleotide polymorphism array in cancer.
Zheng HT, Peng ZH, Li S, He L. Zheng HT, et al. World J Gastroenterol. 2005 Nov 21;11(43):6740-4. doi: 10.3748/wjg.v11.i43.6740. World J Gastroenterol. 2005. PMID: 16425377 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Other Literature Sources
Medical