Existence of phosphoinositide-specific phospholipase C in rat liver nuclei and its change during liver regeneration - PubMed (original) (raw)
Existence of phosphoinositide-specific phospholipase C in rat liver nuclei and its change during liver regeneration
H Kuriki et al. J Biochem. 1992 Mar.
Free article
Abstract
We found phosphoinositide-specific phospholipase C (PtdIns-PLC) activity in nuclei isolated from rat liver. The enzyme hydrolyzed phosphatidylinositol, phosphatidylinositol 4-monophosphate (PIP) and phosphatidylinositol 4,5-bisphosphate in a Ca(2+)-dependent manner, and produced inositol mono-, bis-, and triphosphate, respectively. Neither phosphatidylcholine, phosphatidylethanolamine, nor phosphatidylserine was utilized as a substrate. After partial hepatectomy, the PtdIns-PLC activity in isolated nuclei increased transiently in the S phase (20-22 h post-hepatectomy), to 2.5-fold higher than in the control, when measured with PIP. This result suggests a close relationship between the nuclear PtdIns-PLC, especially its PIP-hydrolyzing activity, and cell proliferation.
Similar articles
- Purification and characterization of nuclear phospholipase C specific for phosphoinositides.
Asano M, Tamiya-Koizumi K, Homma Y, Takenawa T, Nimura Y, Kojima K, Yoshida S. Asano M, et al. J Biol Chem. 1994 Apr 22;269(16):12360-6. J Biol Chem. 1994. PMID: 8163540 - Involvement of nuclear phosphatidylinositol-dependent phospholipases C in cell cycle progression during rat liver regeneration.
Albi E, Rossi G, Maraldi NM, Magni MV, Cataldi S, Solimando L, Zini N. Albi E, et al. J Cell Physiol. 2003 Nov;197(2):181-8. doi: 10.1002/jcp.10292. J Cell Physiol. 2003. PMID: 14502557 - Changes of nuclear PI-PLC gamma1 during rat liver regeneration.
Neri LM, Ricci D, Carini C, Marchisio M, Capitani S, Bertagnolo V. Neri LM, et al. Cell Signal. 1997 Aug;9(5):353-62. doi: 10.1016/s0898-6568(96)00178-7. Cell Signal. 1997. PMID: 9376214 - Regulation of phosphoinositide-specific phospholipase C.
Rhee SG. Rhee SG. Annu Rev Biochem. 2001;70:281-312. doi: 10.1146/annurev.biochem.70.1.281. Annu Rev Biochem. 2001. PMID: 11395409 Free PMC article. Review. - Nuclear phospholipase C signaling through type 1 IGF receptor and its involvement in cell growth and differentiation.
Faenza I, Billi AM, Follo MY, Fiume R, Martelli AM, Cocco L, Manzoli L. Faenza I, et al. Anticancer Res. 2005 May-Jun;25(3B):2039-41. Anticancer Res. 2005. PMID: 16158942 Review.
Cited by
- IL1-beta and TNF-alpha induce changes in the nuclear polyphosphoinositide signalling system in osteoblasts similar to that occurring in patients with rheumatoid arthritis: an immunochemical and immunocytochemical study.
Zini N, Lisignoli G, Solimando L, Bavelloni A, Grassi F, Guidotti L, Trimarchi C, Facchini A, Maraldi NM. Zini N, et al. Histochem Cell Biol. 2003 Sep;120(3):243-50. doi: 10.1007/s00418-003-0563-y. Epub 2003 Aug 12. Histochem Cell Biol. 2003. PMID: 12915944 - Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors.
Boronenkov IV, Loijens JC, Umeda M, Anderson RA. Boronenkov IV, et al. Mol Biol Cell. 1998 Dec;9(12):3547-60. doi: 10.1091/mbc.9.12.3547. Mol Biol Cell. 1998. PMID: 9843587 Free PMC article. - Nucleus-associated phosphorylation of Ins(1,4,5)P3 to InsP6 in Dictyostelium.
Van der Kaay J, Wesseling J, Van Haastert PJ. Van der Kaay J, et al. Biochem J. 1995 Dec 15;312 ( Pt 3)(Pt 3):911-7. Biochem J. 1995. PMID: 8554538 Free PMC article. - Nuclear diacylglycerol is increased during cell proliferation in vivo.
Banfić H, Zizak M, Divecha N, Irvine RF. Banfić H, et al. Biochem J. 1993 Mar 15;290 ( Pt 3)(Pt 3):633-6. doi: 10.1042/bj2900633. Biochem J. 1993. PMID: 8457189 Free PMC article. - Phosphoinositide signalling enzymes in rat liver nuclei: phosphoinositidase C isoform beta 1 is specifically, but not predominantly, located in the nucleus.
Divecha N, Rhee SG, Letcher AJ, Irvine RF. Divecha N, et al. Biochem J. 1993 Feb 1;289 ( Pt 3)(Pt 3):617-20. doi: 10.1042/bj2890617. Biochem J. 1993. PMID: 8382043 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous