The Ku complex is modulated in response to viral infection and other cellular changes - PubMed (original) (raw)
The Ku complex is modulated in response to viral infection and other cellular changes
J P Quinn et al. Biochim Biophys Acta. 1992.
Abstract
The complex of Ku with DNA is demonstrated to have multiple forms as assayed by gel retardation analysis. In CV1 cells this variation of complex can be modulated in response to viral infection with SV40. By Western blot analysis, a correlation can be made between modification of the complex formed on DNA in response to viral infection with variation of the 85 kDa subunit of Ku. Modification of the 85 kDa subunit can also be seen when cells are exposed to various extracellular stimuli including variation in serum levels, PMA and CaPO4.
Similar articles
- The 86-kD subunit of Ku autoantigen mediates homotypic and heterotypic adhesion of multiple myeloma cells.
Teoh G, Urashima M, Greenfield EA, Nguyen KA, Lee JF, Chauhan D, Ogata A, Treon SP, Anderson KC. Teoh G, et al. J Clin Invest. 1998 Mar 15;101(6):1379-88. J Clin Invest. 1998. PMID: 9502780 Free PMC article. - Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication.
Matheos D, Ruiz MT, Price GB, Zannis-Hadjopoulos M. Matheos D, et al. Biochim Biophys Acta. 2002 Oct 11;1578(1-3):59-72. doi: 10.1016/s0167-4781(02)00497-9. Biochim Biophys Acta. 2002. PMID: 12393188 - A constitutive heat shock element-binding factor is immunologically identical to the Ku autoantigen.
Kim D, Ouyang H, Yang SH, Nussenzweig A, Burgman P, Li GC. Kim D, et al. J Biol Chem. 1995 Jun 23;270(25):15277-84. doi: 10.1074/jbc.270.25.15277. J Biol Chem. 1995. PMID: 7797514 - Antibodies to the p70/p80 (Ku) antigens in systemic lupus erythematosus.
Reeves WH. Reeves WH. Rheum Dis Clin North Am. 1992 May;18(2):391-414. Rheum Dis Clin North Am. 1992. PMID: 1626075 Review. - [Anti-Ku antibodies].
Suwa A, Mimori T. Suwa A, et al. Nihon Rinsho. 1999 Nov;57 Suppl:450-2. Nihon Rinsho. 1999. PMID: 10635880 Review. Japanese. No abstract available.
Cited by
- Production and characterization of recombinant human Ku antigen.
Ono M, Tucker PW, Capra JD. Ono M, et al. Nucleic Acids Res. 1994 Sep 25;22(19):3918-24. doi: 10.1093/nar/22.19.3918. Nucleic Acids Res. 1994. PMID: 7937112 Free PMC article. - Ku86 exists as both a full-length and a protease-sensitive natural variant in multiple myeloma cells.
Gullo CA, Ge F, Cow G, Teoh G. Gullo CA, et al. Cancer Cell Int. 2008 Apr 29;8:4. doi: 10.1186/1475-2867-8-4. Cancer Cell Int. 2008. PMID: 18442416 Free PMC article. - Purification of the sequence-specific transcription factor CTCBF, involved in the control of human collagen IV genes: subunits with homology to Ku antigen.
Genersch E, Eckerskorn C, Lottspeich F, Herzog C, Kühn K, Pöschl E. Genersch E, et al. EMBO J. 1995 Feb 15;14(4):791-800. doi: 10.1002/j.1460-2075.1995.tb07057.x. EMBO J. 1995. PMID: 7882982 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous