Principles of cytomegalovirus antigen presentation in vitro and in vivo - PubMed (original) (raw)
Affiliations
- PMID: 1319768
Review
Principles of cytomegalovirus antigen presentation in vitro and in vivo
U H Koszinowski et al. Semin Immunol. 1992 Apr.
Abstract
Cytomegaloviruses are members of the ubiquitous family of herpesviruses. They escape immunological clearance and persist throughout life in the infected host. Yet, the stability of the balance of this virus-host interaction is dependent upon the state of the cellular immune response, and usually requires the function of specific CD8 T lymphocytes. In a mouse model, the major antigen that triggers protective CD8 T lymphocytes has been characterized as a nonameric amino acid motif of a nonstructural virus protein. Analysis of the naturally presented peptide has led to the conclusion that the sequence of an antigenic epitope is not the only parameter that decides upon its efficient presentation. Furthermore, the virus has developed regulatory functions that can prevent antigen presentation in productively infected cells. Contradictions between in vivo and in vitro findings are resolved in a hypothesis postulating an essential contribution of cytokines to the in vivo control of productive cytomegalovirus infection.
Similar articles
- In vivo impact of cytomegalovirus evasion of CD8 T-cell immunity: facts and thoughts based on murine models.
Lemmermann NA, Böhm V, Holtappels R, Reddehase MJ. Lemmermann NA, et al. Virus Res. 2011 May;157(2):161-74. doi: 10.1016/j.virusres.2010.09.022. Epub 2010 Oct 8. Virus Res. 2011. PMID: 20933556 Review. - Positive selection of cytotoxic T lymphocyte escape variants during acute hepatitis C virus infection.
Guglietta S, Garbuglia AR, Pacciani V, Scottà C, Perrone MP, Laurenti L, Spada E, Mele A, Capobianchi MR, Taliani G, Folgori A, Vitelli A, Ruggeri L, Nicosia A, Piccolella E, Del Porto P. Guglietta S, et al. Eur J Immunol. 2005 Sep;35(9):2627-37. doi: 10.1002/eji.200526067. Eur J Immunol. 2005. PMID: 16114108 - Immune escape and exploitation strategies of cytomegaloviruses: impact on and imitation of the major histocompatibility system.
Mocarski ES Jr. Mocarski ES Jr. Cell Microbiol. 2004 Aug;6(8):707-17. doi: 10.1111/j.1462-5822.2004.00425.x. Cell Microbiol. 2004. PMID: 15236638 Review. - Cytomegalovirus misleads its host by priming of CD8 T cells specific for an epitope not presented in infected tissues.
Holtappels R, Podlech J, Pahl-Seibert MF, Jülch M, Thomas D, Simon CO, Wagner M, Reddehase MJ. Holtappels R, et al. J Exp Med. 2004 Jan 5;199(1):131-6. doi: 10.1084/jem.20031582. Epub 2003 Dec 29. J Exp Med. 2004. PMID: 14699084 Free PMC article. - Flow-microfluorometric monitoring of oligoclonal CD8+ T cell responses to an immunodominant Moloney leukemia virus-encoded epitope in vivo.
Brawand P, Biasi G, Horvath C, Cerottini JC, MacDonald HR. Brawand P, et al. J Immunol. 1998 Feb 15;160(4):1659-65. J Immunol. 1998. PMID: 9469422
Cited by
- Experimental preemptive immunotherapy of murine cytomegalovirus disease with CD8 T-cell lines specific for ppM83 and pM84, the two homologs of human cytomegalovirus tegument protein ppUL83 (pp65).
Holtappels R, Podlech J, Grzimek NK, Thomas D, Pahl-Seibert MF, Reddehase MJ. Holtappels R, et al. J Virol. 2001 Jul;75(14):6584-600. doi: 10.1128/JVI.75.14.6584-6600.2001. J Virol. 2001. PMID: 11413326 Free PMC article. - Enrichment of immediate-early 1 (m123/pp89) peptide-specific CD8 T cells in a pulmonary CD62L(lo) memory-effector cell pool during latent murine cytomegalovirus infection of the lungs.
Holtappels R, Pahl-Seibert MF, Thomas D, Reddehase MJ. Holtappels R, et al. J Virol. 2000 Dec;74(24):11495-503. doi: 10.1128/jvi.74.24.11495-11503.2000. J Virol. 2000. PMID: 11090146 Free PMC article. - Dense bodies of human cytomegalovirus induce both humoral and cellular immune responses in the absence of viral gene expression.
Pepperl S, Münster J, Mach M, Harris JR, Plachter B. Pepperl S, et al. J Virol. 2000 Jul;74(13):6132-46. doi: 10.1128/jvi.74.13.6132-6146.2000. J Virol. 2000. PMID: 10846097 Free PMC article. - Suppression of murine cytomegalovirus (MCMV) replication with a DNA vaccine encoding MCMV M84 (a homolog of human cytomegalovirus pp65).
Morello CS, Cranmer LD, Spector DH. Morello CS, et al. J Virol. 2000 Apr;74(8):3696-708. doi: 10.1128/jvi.74.8.3696-3708.2000. J Virol. 2000. PMID: 10729145 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Research Materials