The p70 tumor necrosis factor receptor mediates cytotoxicity - PubMed (original) (raw)
Comparative Study
. 1992 Jul 10;70(1):47-56.
doi: 10.1016/0092-8674(92)90532-h.
Affiliations
- PMID: 1320461
- DOI: 10.1016/0092-8674(92)90532-h
Comparative Study
The p70 tumor necrosis factor receptor mediates cytotoxicity
R A Heller et al. Cell. 1992.
Abstract
Tumor necrosis factor alpha (TNF) selectively kills tumor cells, but this specificity is not clearly understood. Two distinctly different cell surface receptors (TNFRs), proteins of 55 kd (p55) and 70-80 kd (p70), mediate TNF action. Mouse TA1 cells are not killed by human (h) TNF, but are killed by mouse (m) TNF alone. Since the mouse p70 TNFR is recognized only by mTNF, these results implicate p70 receptor action in TA1 cell killing. Human HeLa cells have mainly the p55 receptor and are not killed by hTNF alone. When transfected with the human p70 TNFR, HeLa p70 die within 24 hr. HeLa p70 cells also show reduced c-fos and manganous superoxide dismutase induction by TNF. NIH 3T3 mouse fibroblasts are sensitive to only mTNF, but overexpression of the human p70 receptor causes cell death by hTNF and increased sensitivity to mTNF. These results provide a direct function for the p70 TNFR in TNF-induced cytotoxicity.
Similar articles
- HIV type 1 Tat inhibits tumor necrosis factor alpha-induced repression of tumor necrosis factor receptor p55 and amplifies tumor necrosis factor alpha activity in stably tat-transfected HeLa Cells.
Chiao C, Bader T, Stenger JE, Baldwin W, Brady J, Barrett JC. Chiao C, et al. AIDS Res Hum Retroviruses. 2001 Aug 10;17(12):1125-32. doi: 10.1089/088922201316912736. AIDS Res Hum Retroviruses. 2001. PMID: 11522182 - Cytotoxicity in L929 murine fibrosarcoma cells after triggering of transfected human p75 tumour necrosis factor (TNF) receptor is mediated by endogenous murine TNF.
Vercammen D, Vandenabeele P, Declercq W, Van de Craen M, Grooten J, Fiers W. Vercammen D, et al. Cytokine. 1995 Jul;7(5):463-70. doi: 10.1006/cyto.1995.0063. Cytokine. 1995. PMID: 7578985 - The two different receptors for tumor necrosis factor mediate distinct cellular responses.
Tartaglia LA, Weber RF, Figari IS, Reynolds C, Palladino MA Jr, Goeddel DV. Tartaglia LA, et al. Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):9292-6. doi: 10.1073/pnas.88.20.9292. Proc Natl Acad Sci U S A. 1991. PMID: 1718003 Free PMC article. - Functional requirement of the two TNF receptors for induction of apoptosis in PC60 cells and the role of mitochondria in TNF-induced cytotoxicity.
Vandenabeele P, Goossens V, Beyaert R, Declercq W, Grooten J, Vanhaesebroeck B, Van de Craen M, Vercammen D, Depuydt B, Denecker G, et al. Vandenabeele P, et al. Circ Shock. 1994 Dec;44(4):196-200. Circ Shock. 1994. PMID: 7628061 Review.
Cited by
- Immunohistochemical localization and possible physiological roles of tumor necrosis factor-α in mouse cumulus-oocyte complexes.
Sato E, Nakayama T, Kamio K, Takahashi Y, Toyoda Y. Sato E, et al. Dev Growth Differ. 1995 Aug;37(4):413-420. doi: 10.1046/j.1440-169X.1995.t01-3-00008.x. Dev Growth Differ. 1995. PMID: 37282325 - Antileukemic Natural Product Induced Both Apoptotic and Pyroptotic Programmed Cell Death and Differentiation Effect.
Leu WJ, Chang HS, Chen IS, Guh JH, Chan SH. Leu WJ, et al. Int J Mol Sci. 2021 Oct 18;22(20):11239. doi: 10.3390/ijms222011239. Int J Mol Sci. 2021. PMID: 34681898 Free PMC article. - Role of tumor necrosis factor-α in Gram-negative bacterial lipopolysaccharides induced implantation failure.
Deb K, Chaturvedi MM, Jaiswal YK. Deb K, et al. Reprod Med Biol. 2005 Mar 7;4(1):79-88. doi: 10.1007/BF03016141. eCollection 2005 Mar. Reprod Med Biol. 2005. PMID: 29662387 Free PMC article. - Tight association between macrophages and adipocytes in obesity: implications for adipocyte preparation.
Ebke LA, Nestor-Kalinoski AL, Slotterbeck BD, Al-Dieri AG, Ghosh-Lester S, Russo L, Najjar SM, von Grafenstein H, McInerney MF. Ebke LA, et al. Obesity (Silver Spring). 2014 May;22(5):1246-55. doi: 10.1002/oby.20634. Epub 2013 Dec 4. Obesity (Silver Spring). 2014. PMID: 24376179 Free PMC article. - A TRAF2 binding independent region of TNFR2 is responsible for TRAF2 depletion and enhancement of cytotoxicity driven by TNFR1.
Cabal-Hierro L, Artime N, Iglesias J, Prado MA, Ugarte-Gil L, Casado P, Fernández-García B, Darnay BG, Lazo PS. Cabal-Hierro L, et al. Oncotarget. 2014 Jan 15;5(1):224-36. doi: 10.18632/oncotarget.1492. Oncotarget. 2014. PMID: 24318359 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources