Hepatic expression of type A and type B receptors for tumor necrosis factor - PubMed (original) (raw)
Hepatic expression of type A and type B receptors for tumor necrosis factor
R Volpes et al. J Hepatol. 1992 Mar.
Abstract
We have examined the in-situ distribution of type A and type B receptors for tumor necrosis factor (TNF) in normal and diseased human liver biopsy specimens. In normal liver tissue, no or very small amounts of TNF receptors were found. In acute and chronic inflammatory liver diseases, a strong up-regulation of the expression of both TNF receptors was found on hepatocytes, bile duct epithelium, sinusoidal lining cells and mononuclear inflammatory cells. With immunoelectronmicroscopy, all these cells showed cytoplasmic, in addition to membranous staining, suggesting active synthesis of the receptor or, alternatively, internalization of the receptor and its ligand. This up-regulated expression of both type A and type B receptors for TNF was similar in acute and chronic active hepatitis, and was not related to the etiology of the liver disease, nor restricted to areas of liver inflammation. Our results indicate that hepatocytes, sinusoidal endothelial cells, bile duct epithelial cells and mononuclear inflammatory cells, by displaying receptors for TNFs, represent target cells for both these cytokines. Up-regulated expression of type A and type B receptors for TNFs endows these cells with augmented responsiveness for the pleiomorphic biological activities of these cytokines during liver injury.
Similar articles
- Serum levels and in situ expression of TNF-alpha and TNF-alpha binding proteins in inflammatory liver diseases.
Spengler U, Zachoval R, Gallati H, Jung MC, Hoffmann R, Riethmüller G, Pape G. Spengler U, et al. Cytokine. 1996 Nov;8(11):864-72. doi: 10.1006/cyto.1996.0115. Cytokine. 1996. PMID: 9047083 - Phenotypical analysis and cytokine release of liver-infiltrating and peripheral blood T lymphocytes from patients with chronic hepatitis of different etiology.
Löhr HF, Schlaak JF, Gerken G, Fleischer B, Dienes HP, Meyer zum Büschenfelde KH. Löhr HF, et al. Liver. 1994 Jun;14(3):161-6. doi: 10.1111/j.1600-0676.1994.tb00067.x. Liver. 1994. PMID: 8078396 - Analysis of proliferating biliary epithelial cells in human liver disease using a monoclonal antibody against DNA polymerase alpha.
Seki S, Sakaguchi H, Kawakita N, Yanai A, Kuroki T, Kobayashi K. Seki S, et al. Virchows Arch A Pathol Anat Histopathol. 1993;422(2):133-43. doi: 10.1007/BF01607165. Virchows Arch A Pathol Anat Histopathol. 1993. PMID: 7682020 - Decoding cell death signals in liver inflammation.
Brenner C, Galluzzi L, Kepp O, Kroemer G. Brenner C, et al. J Hepatol. 2013 Sep;59(3):583-94. doi: 10.1016/j.jhep.2013.03.033. Epub 2013 Apr 6. J Hepatol. 2013. PMID: 23567086 Review. - [Hepatic neoductules].
Fischer HP, Meybehm M, Zhou H, Schoch J. Fischer HP, et al. Verh Dtsch Ges Pathol. 1995;79:36-46. Verh Dtsch Ges Pathol. 1995. PMID: 8600693 Review. German.
Cited by
- Soluble tumor necrosis factor receptors in patients with recurrent hepatitis C virus infection after liver transplantation.
Arnold JC, Heilig B, Kallinowski B, Otto G, Kommerell B, Theilmann L. Arnold JC, et al. Clin Investig. 1994 Jun;72(6):470. doi: 10.1007/BF00180524. Clin Investig. 1994. PMID: 7950161 No abstract available. - Characterization of the host proinflammatory response to tumor cells during the initial stages of liver metastasis.
Khatib AM, Auguste P, Fallavollita L, Wang N, Samani A, Kontogiannea M, Meterissian S, Brodt P. Khatib AM, et al. Am J Pathol. 2005 Sep;167(3):749-59. doi: 10.1016/S0002-9440(10)62048-2. Am J Pathol. 2005. PMID: 16127154 Free PMC article. - Activation of tumor necrosis factor-alpha system in chronic hepatitis C virus infection.
Nelson DR, Lim HL, Marousis CG, Fang JW, Davis GL, Shen L, Urdea MS, Kolberg JA, Lau JY. Nelson DR, et al. Dig Dis Sci. 1997 Dec;42(12):2487-94. doi: 10.1023/a:1018804426724. Dig Dis Sci. 1997. PMID: 9440625 - Induction of tumour necrosis factor (TNF) receptor type p55 and p75 in patients with chronic hepatitis C virus (HCV) infection.
Kallinowski B, Haseroth K, Marinos G, Hanck C, Stremmel W, Theilmann L, Singer MV, Rossol S. Kallinowski B, et al. Clin Exp Immunol. 1998 Feb;111(2):269-77. doi: 10.1046/j.1365-2249.1998.00469.x. Clin Exp Immunol. 1998. PMID: 9486392 Free PMC article. - Prominent Receptors of Liver Sinusoidal Endothelial Cells in Liver Homeostasis and Disease.
Pandey E, Nour AS, Harris EN. Pandey E, et al. Front Physiol. 2020 Jul 21;11:873. doi: 10.3389/fphys.2020.00873. eCollection 2020. Front Physiol. 2020. PMID: 32848838 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical