Detection and biochemical characterization of the mouse mammary tumor virus 7 superantigen (Mls-1a) - PubMed (original) (raw)
Detection and biochemical characterization of the mouse mammary tumor virus 7 superantigen (Mls-1a)
G M Winslow et al. Cell. 1992.
Abstract
Mouse mammary tumor viruses encode superantigens that bind to class II major histocompatibility complex proteins and engage T cells that bear particular V beta s. Among these superantigens is the long known, but previously uncharacterized, Mls-1a product, encoded by Mtv-7. Using a monoclonal antibody, we detect the Mtv-7 superantigen on the surface of activated B cells, but not on T cells or resting B cells. The superantigen is synthesized as a 45 kd transmembrane glycoprotein precursor, but is proteolytically processed to yield an 18.5 kd surface protein that we suggest is the functional form of the superantigen.
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