Ubiquitin-positive intraneuronal inclusions in the extramotor cortices of presenile dementia patients with motor neuron disease - PubMed (original) (raw)

. 1992 Oct;239(8):426-30.

doi: 10.1007/BF00856806.

Affiliations

• PMID: 1333007
• DOI: 10.1007/BF00856806

Ubiquitin-positive intraneuronal inclusions in the extramotor cortices of presenile dementia patients with motor neuron disease

K Okamoto et al. J Neurol. 1992 Oct.

Abstract

Ubiquitin-positive intraneuronal inclusions were found in the extramotor cortices of ten presenile dementia patients with motor neuron disease. There were inclusions in the hippocampal granular cells and in the small neurons of the superficial layers of the temporal and frontal cortices. Bunina bodies were present in the anterior horn cells in all cases. These results suggest that ubiquitin-related cytoskeletal abnormalities are common in cerebral non-motor small neurons in these patients.

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References

1. 1. Acta Neurol Scand. 1985 Jun;71(6):480-4 - PubMed
2. 1. Ann Neurol. 1990 Feb;27(2):137-48 - PubMed
3. 1. J Neurol Neurosurg Psychiatry. 1990 Jan;53(1):23-32 - PubMed
4. 1. Neurology. 1990 Feb;40(2):251-6 - PubMed
5. 1. Arch Gerontol Geriatr. 1987 Sep;6(3):263-77 - PubMed

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