[The central thermoregulatory action of cholecystokinin-8 and prostaglandin E1] - PubMed (original) (raw)
[Article in Russian]
- PMID: 1334868
Comparative Study
[The central thermoregulatory action of cholecystokinin-8 and prostaglandin E1]
[Article in Russian]
Z Szelényi et al. Fiziol Zh SSSR Im I M Sechenova. 1992 Apr.
Abstract
In unanesthetized rats, the effects of intracerebroventricular injections of prostaglandin E1 (PGE1) and cholecystokinin octapeptide (CCK-8) on body temperature (Tb) regulation were studied. Both PGE1 and CCK-8 evoke hyperthermic responses of short latency and duration. Each substance raises the temperature, irrespective of initial temperature (Tbi). However, the maximal change in Tb and the rate of Tb rise depends on Tbi. A similarity of PGE1 and CCK-8 central thermoregulatory effects and putative roles of these substances in the mechanisms of fever, are discussed.
Similar articles
- Cholecystokinin octapeptide (CCK-8) injected into a cerebral ventricle induces a fever-like thermoregulatory response mediated by type B CCK-receptors in the rat.
Szelényi Z, Barthó L, Székely M, Romanovsky AA. Szelényi Z, et al. Brain Res. 1994 Feb 28;638(1-2):69-77. doi: 10.1016/0006-8993(94)90634-3. Brain Res. 1994. PMID: 8199877 - CCK-8 and PGE1: central effects on circadian body temperature and activity rhythms in rats.
Szelényi Z, Hummel Z, Székely M, Pétervári E. Szelényi Z, et al. Physiol Behav. 2004 Jun;81(4):615-21. doi: 10.1016/j.physbeh.2004.02.025. Physiol Behav. 2004. PMID: 15178154 - Systemic administration of prostaglandin E1 produces hypothermic effects in unanesthetized rats.
Lin MT. Lin MT. J Pharmacol Exp Ther. 1979 Jun;209(3):349-51. J Pharmacol Exp Ther. 1979. PMID: 439011 - Normal body temperature of rats: the setpoint controversy.
Briese E. Briese E. Neurosci Biobehav Rev. 1998 May;22(3):427-36. doi: 10.1016/s0149-7634(97)00051-1. Neurosci Biobehav Rev. 1998. PMID: 9579330 Review. - Ethanol, body temperature and thermoregulation.
Crawshaw LI, Wallace H, Crabbe J. Crawshaw LI, et al. Clin Exp Pharmacol Physiol. 1998 Feb;25(2):150-4. doi: 10.1111/j.1440-1681.1998.tb02195.x. Clin Exp Pharmacol Physiol. 1998. PMID: 9493506 Review.
Cited by
- Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: a novel hypothesis on the mechanism of hot flushes.
Rance NE, Dacks PA, Mittelman-Smith MA, Romanovsky AA, Krajewski-Hall SJ. Rance NE, et al. Front Neuroendocrinol. 2013 Aug;34(3):211-27. doi: 10.1016/j.yfrne.2013.07.003. Epub 2013 Jul 17. Front Neuroendocrinol. 2013. PMID: 23872331 Free PMC article. Review. - The transient receptor potential vanilloid-1 channel in thermoregulation: a thermosensor it is not.
Romanovsky AA, Almeida MC, Garami A, Steiner AA, Norman MH, Morrison SF, Nakamura K, Burmeister JJ, Nucci TB. Romanovsky AA, et al. Pharmacol Rev. 2009 Sep;61(3):228-61. doi: 10.1124/pr.109.001263. Epub 2009 Sep 11. Pharmacol Rev. 2009. PMID: 19749171 Free PMC article. Review. - Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors.
Steiner AA, Turek VF, Almeida MC, Burmeister JJ, Oliveira DL, Roberts JL, Bannon AW, Norman MH, Louis JC, Treanor JJ, Gavva NR, Romanovsky AA. Steiner AA, et al. J Neurosci. 2007 Jul 11;27(28):7459-68. doi: 10.1523/JNEUROSCI.1483-07.2007. J Neurosci. 2007. PMID: 17626206 Free PMC article.