Characterization of the yeast SWI1, SWI2, and SWI3 genes, which encode a global activator of transcription - PubMed (original) (raw)
Characterization of the yeast SWI1, SWI2, and SWI3 genes, which encode a global activator of transcription
C L Peterson et al. Cell. 1992.
Abstract
The yeast SWI1, SWI2 (SNF2), and SWI3 genes are required for transcription of HO and INO1 genes. We show that they are also required for transcription of ADH1, ADH2, SUC2, GAL1, and GAL10 and for function of simple UAS elements with binding sites for yeast GAL4 or Drosophila ftz proteins. SWI3 encodes a 99 kd nuclear protein containing a large, highly acidic N-terminal domain. SWI1 is identical to ADR6, which encodes a positive regulator of ADH1 and ADH2. Transcription of HO also requires SNF5 and SNF6. These and other observations suggest that SWI1, SWI2, SWI3, SNF5, and SNF6 may be components of a large multi-subunit complex. We propose that these products perform a general role in transcription by assisting gene-specific regulatory proteins.
Similar articles
- A multisubunit complex containing the SWI1/ADR6, SWI2/SNF2, SWI3, SNF5, and SNF6 gene products isolated from yeast.
Cairns BR, Kim YJ, Sayre MH, Laurent BC, Kornberg RD. Cairns BR, et al. Proc Natl Acad Sci U S A. 1994 Mar 1;91(5):1950-4. doi: 10.1073/pnas.91.5.1950. Proc Natl Acad Sci U S A. 1994. PMID: 8127913 Free PMC article. - Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor.
Chiba H, Muramatsu M, Nomoto A, Kato H. Chiba H, et al. Nucleic Acids Res. 1994 May 25;22(10):1815-20. doi: 10.1093/nar/22.10.1815. Nucleic Acids Res. 1994. PMID: 8208605 Free PMC article. - Interaction of a Swi3 homolog with Sth1 provides evidence for a Swi/Snf-related complex with an essential function in Saccharomyces cerevisiae.
Treich I, Carlson M. Treich I, et al. Mol Cell Biol. 1997 Apr;17(4):1768-75. doi: 10.1128/MCB.17.4.1768. Mol Cell Biol. 1997. PMID: 9121424 Free PMC article. - DNA replication: stalling a fork for imprinting and switching.
Egel R. Egel R. Curr Biol. 2004 Nov 9;14(21):R915-7. doi: 10.1016/j.cub.2004.10.012. Curr Biol. 2004. PMID: 15530381 Review. - The expression of homologous and heterologous genes in yeast.
Kingsman AJ, Stanway C, Kingsman SM. Kingsman AJ, et al. Antonie Van Leeuwenhoek. 1987;53(5):325-33. doi: 10.1007/BF00400556. Antonie Van Leeuwenhoek. 1987. PMID: 3318689 Review. No abstract available.
Cited by
- Transcriptional activation domains interact with ATPase subunits of yeast chromatin remodelling complexes SWI/SNF, RSC and INO80.
Wendegatz EC, Engelhardt M, Schüller HJ. Wendegatz EC, et al. Curr Genet. 2024 Sep 5;70(1):15. doi: 10.1007/s00294-024-01300-x. Curr Genet. 2024. PMID: 39235627 Free PMC article. - Chromatin remodellers as therapeutic targets.
Malone HA, Roberts CWM. Malone HA, et al. Nat Rev Drug Discov. 2024 Sep;23(9):661-681. doi: 10.1038/s41573-024-00978-5. Epub 2024 Jul 16. Nat Rev Drug Discov. 2024. PMID: 39014081 Review. - Context-specific functions of chromatin remodellers in development and disease.
Gourisankar S, Krokhotin A, Wenderski W, Crabtree GR. Gourisankar S, et al. Nat Rev Genet. 2024 May;25(5):340-361. doi: 10.1038/s41576-023-00666-x. Epub 2023 Nov 24. Nat Rev Genet. 2024. PMID: 38001317 Review. - The BAF chromatin remodeling complex licenses planarian stem cells access to ectodermal and mesodermal cell fates.
Wiggans M, Zhu SJ, Molinaro AM, Pearson BJ. Wiggans M, et al. BMC Biol. 2023 Oct 20;21(1):227. doi: 10.1186/s12915-023-01730-y. BMC Biol. 2023. PMID: 37864247 Free PMC article. - Differential Contributions of mSWI/SNF Chromatin Remodeler Sub-Families to Myoblast Differentiation.
Padilla-Benavides T, Olea-Flores M, Sharma T, Syed SA, Witwicka H, Zuñiga-Eulogio MD, Zhang K, Navarro-Tito N, Imbalzano AN. Padilla-Benavides T, et al. Int J Mol Sci. 2023 Jul 9;24(14):11256. doi: 10.3390/ijms241411256. Int J Mol Sci. 2023. PMID: 37511016 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous