The basic region of AP-1 specifies glucocorticoid receptor activity at a composite response element - PubMed (original) (raw)

. 1992 Dec;6(12B):2491-501.

doi: 10.1101/gad.6.12b.2491.

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The basic region of AP-1 specifies glucocorticoid receptor activity at a composite response element

J N Miner et al. Genes Dev. 1992 Dec.

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Abstract

Unrelated factors collaborate at composite response elements to confer novel patterns of transcriptional regulation. For example, AP-1 and glucocorticoid receptor bind and mutually affect their activities at a 25-bp composite element, plfG. We found that different members of the AP-1 factor family that behave similarly in the absence of receptor are strikingly distinct in its presence: They specify opposite (enhancement vs. repression) regulatory actions by the receptor. Four amino acids within the AP-1 DNA-binding domain were identified as crucial determinants of receptor regulatory activity at plfG. We conclude that interactions of factors from separate transcription factor families at composite response elements provide a mechanism by which a single factor can regulate both positively or negatively, and a potential resolution of the apparent functional redundancy within regulatory factor families.

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