Isolation and mapping of 68 RFLP markers on human chromosome 6 - PubMed (original) (raw)
Isolation and mapping of 68 RFLP markers on human chromosome 6
S Saito et al. Am J Hum Genet. 1992 Jan.
Abstract
We have isolated 68 new RFLP markers on human chromosome 6. Of these, 64 were localized on chromosomal bands by the fluorescent in-situ hybridization (FISH) method, 25 on the short arm and 39 on the long arm. Their distribution was uneven; the markers were localized predominantly in regions of R-positive banding. Eleven markers defined VNTR loci. This expanded collection of DNA markers will contribute to high-resolution linkage mapping of genes causing inherited disorders and will provide useful reagents for isolation of putative tumor-suppressor genes on chromosome 6 that appear to be involved in malignancies. Furthermore, the new markers will be guideposts for detailed linkage and physical maps of this chromosome.
References
- Am J Hum Genet. 1991 Feb;48(2):258-68 - PubMed
- Genomics. 1991 Mar;9(3):536-43 - PubMed
- Genomics. 1991 Apr;9(4):713-20 - PubMed
- Genomics. 1991 Mar;9(3):420-8 - PubMed
- Science. 1990 Feb 2;247(4942):568-71 - PubMed
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