Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6 - PubMed (original) (raw)
. 1992 Feb 6;355(6360):516-20.
doi: 10.1038/355516a0.
Affiliations
- PMID: 1346922
- DOI: 10.1038/355516a0
Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6
O Chisaka et al. Nature. 1992.
Abstract
Gene targeting in mouse embryo-derived stem cells has been used to generate mice with a disruption in the homeobox gene Hox-1.6. Mice heterozygous at the Hox-1.6 locus appear normal, whereas Hox-1.6-/Hox-1.6- mice die at or shortly after birth. These homozygotes exhibit profound defects in the formation of the external, middle and inner ears as well as in specific hindbrain nuclei, and in cranial nerves and ganglia. The affected tissues lie within a narrow region along the anteroposterior axis of the mouse but are of diverse embryonic origin. The set of defects associated with the disruption of Hox-1.6 is distinct from and nonoverlapping with that of the closely linked Hox-1.5 gene. But both mutations cause loss, rather than homeotic transformation, of tissues and structures.
Comment in
- Developmental biology. The making of the ear.
Hogan B, Wright C. Hogan B, et al. Nature. 1992 Feb 6;355(6360):494-5. doi: 10.1038/355494a0. Nature. 1992. PMID: 1346921 No abstract available.
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