Synthesis and release of neuroactive substances by glial cells - PubMed (original) (raw)

Review

Synthesis and release of neuroactive substances by glial cells

D L Martin. Glia. 1992.

Abstract

Glia contain, synthesize, or release more than 20 neuroactive compounds including neuropeptides, amino acid transmitters, eicosanoids, steroids, and growth factors. The stimuli that elicit release differ among compounds but include neuropeptides, neurotransmitters, receptor agonists, and elevated external [K+]. The mechanisms of release are poorly understood in most cases. Many of the neuroactive compounds are localized in discrete subpopulations of glia. Thus, glia are equipped to send as well as receive chemical messages and appear to be present as classes of cells with differing abilities to communicate chemically. It is possible that glia are as diverse as neurons in their functional characteristics.

PubMed Disclaimer

Similar articles

• Neuropeptides as synaptic transmitters.
  Salio C, Lossi L, Ferrini F, Merighi A. Salio C, et al. Cell Tissue Res. 2006 Nov;326(2):583-98. doi: 10.1007/s00441-006-0268-3. Epub 2006 Jul 18. Cell Tissue Res. 2006. PMID: 16847638 Review.
• Neurotransmitter release.
  Süudhof TC. Süudhof TC. Handb Exp Pharmacol. 2008;(184):1-21. doi: 10.1007/978-3-540-74805-2_1. Handb Exp Pharmacol. 2008. PMID: 18064409 Review.
• Expression of functional receptors and transmitter enzymes in cultured Muller cells.
  Kubrusly RC, da Cunha MC, Reis RA, Soares H, Ventura AL, Kurtenbach E, de Mello MC, de Mello FG. Kubrusly RC, et al. Brain Res. 2005 Mar 21;1038(2):141-9. doi: 10.1016/j.brainres.2005.01.031. Brain Res. 2005. PMID: 15757630
• Basic fibroblast growth factor (bFGF) acts on both neurons and glia to mediate the neurotrophic effects of astrocytes on LHRH neurons in culture.
  Gallo F, Morale MC, Spina-Purrello V, Tirolo C, Testa N, Farinella Z, Avola R, Beaudet A, Marchetti B. Gallo F, et al. Synapse. 2000 Jun 15;36(4):233-53. doi: 10.1002/(SICI)1098-2396(20000615)36:4<233::AID-SYN1>3.0.CO;2-I. Synapse. 2000. PMID: 10819902
• Role of retinal glial cells in neurotransmitter uptake and metabolism.
  Bringmann A, Pannicke T, Biedermann B, Francke M, Iandiev I, Grosche J, Wiedemann P, Albrecht J, Reichenbach A. Bringmann A, et al. Neurochem Int. 2009 Mar-Apr;54(3-4):143-60. doi: 10.1016/j.neuint.2008.10.014. Epub 2008 Dec 9. Neurochem Int. 2009. PMID: 19114072 Review.

Cited by

• Far-red and sensitive sensor for monitoring real time H2O2 dynamics with subcellular resolution and in multi-parametric imaging applications.
  Berndt A, Lee J, Nguyen A, Jin Z, Moghadasi A, Gibbs C, Wait S, Evitts K, Asencio A, Bremner S, Zuniga S, Chavan V, Williams A, Smith A, Moussavi-Harami F, Regnier M, Young J, Mack D, Nance E, Boyle P. Berndt A, et al. Res Sq [Preprint]. 2024 Apr 17:rs.3.rs-3974015. doi: 10.21203/rs.3.rs-3974015/v1. Res Sq. 2024. PMID: 38699332 Free PMC article. Preprint.
• Pressure-Induced Changes in Astrocyte GFAP, Actin, and Nuclear Morphology in Mouse Optic Nerve.
  Ling YTT, Pease ME, Jefferys JL, Kimball EC, Quigley HA, Nguyen TD. Ling YTT, et al. Invest Ophthalmol Vis Sci. 2020 Sep 1;61(11):14. doi: 10.1167/iovs.61.11.14. Invest Ophthalmol Vis Sci. 2020. PMID: 32910133 Free PMC article.
• Reactive Astrocytes as Therapeutic Targets for Brain Degenerative Diseases: Roles Played by Metabotropic Glutamate Receptors.
  Planas-Fontánez TM, Dreyfus CF, Saitta KS. Planas-Fontánez TM, et al. Neurochem Res. 2020 Mar;45(3):541-550. doi: 10.1007/s11064-020-02968-6. Epub 2020 Jan 25. Neurochem Res. 2020. PMID: 31983009 Free PMC article. Review.
• Emergence of Relaxation Oscillations in Neurons Interacting With Non-stationary Ambient GABA.
  Adamchik DA, Matrosov VV, Kazantsev VB. Adamchik DA, et al. Front Comput Neurosci. 2018 Apr 5;12:19. doi: 10.3389/fncom.2018.00019. eCollection 2018. Front Comput Neurosci. 2018. PMID: 29674960 Free PMC article.
• Astroglial vesicular network: evolutionary trends, physiology and pathophysiology.
  Zorec R, Parpura V, Verkhratsky A. Zorec R, et al. Acta Physiol (Oxf). 2018 Feb;222(2):10.1111/apha.12915. doi: 10.1111/apha.12915. Epub 2017 Aug 3. Acta Physiol (Oxf). 2018. PMID: 28665546 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Wiley