Nearly identical T-cell receptor V-gene usage at birth in two cohorts of distinctly different ethnic origin: influence of environment in the final maturation in the adult - PubMed (original) (raw)
Nearly identical T-cell receptor V-gene usage at birth in two cohorts of distinctly different ethnic origin: influence of environment in the final maturation in the adult
N S Ramakrishnan et al. Scand J Immunol. 1992 Jul.
Abstract
We have previously analysed the T-cell receptor (TCR) V-gene usage in peripheral blood T lymphocytes from a group of healthy Scandinavians, and described a biased representation (i.e. a statistically significant higher median representation) for some of the TCR V genes towards the CD4+ subpopulation. In a subsequent study the usage of the same V genes was analysed in single positive (CD4+ CD8- and CD4- CD8+) human thymocytes, and a similar type of skewness was noted. These observations might be explained by an influence of the specificity of the TCR of thymocytes on the maturation into the CD4+ or the CD8+ lineage. Such a model would assume an interaction between a common determinant on the major histocompatibility complex (MHC) class I or class II molecules, or with a peptide that is preferentially presented by either of the two molecules, and the TCR on the maturing thymocyte. To investigate the possible influence of a different genetic background and environment on skewed TCR V-gene representation, we have in this study analysed the TCR V-gene usage in peripheral blood and umbilical cord blood lymphocytes obtained from Asians, with a different ethnic and environmental background from our previous Scandinavian subjects. In the umbilical cord blood lymphocytes the TCR V-gene usage was close to identical between the two different ethnic groups in both CD4+ and CD8+ subpopulations. Analysing the peripheral blood lymphocyte (PBL) TCR V-gene usage, we found that three of the four monoclonal antibodies (MoAb) with a biased reactivity towards the CD4+ subpopulation in the Scandinavian group also showed a similar skewed reactivity in this study. Thus, the majority of the TCR V genes were used in a similar way. Some minor but definite discrepancies could be detected when comparing TCR V-gene usage in adult individuals from these two different ethnic groups. These differences could be inferred to be due to selective peripheral expansion through environmental pressure of T cells utilizing a specific V beta gene segment. We conclude that a striking preservation of biased TCR V-gene usage does exist in humans of distinctly different ethnic origin.
Similar articles
- An analysis of alpha/beta TCR V gene expression in the human thymus.
Grunewald J, Shankar N, Wigzell H, Janson CH. Grunewald J, et al. Int Immunol. 1991 Jul;3(7):699-702. doi: 10.1093/intimm/3.7.699. Int Immunol. 1991. PMID: 1832951 - Differential usage of T cell receptor V gene segments in CD4+ and CD8+ subsets of T lymphocytes in monozygotic twins.
Hawes GE, Struyk L, van den Elsen PJ. Hawes GE, et al. J Immunol. 1993 Mar 1;150(5):2033-45. J Immunol. 1993. PMID: 8436833 - Increased frequency of T cell receptor V alpha 12.1 expression on CD8+ T cells: evidence that V alpha participates in shaping the peripheral T cell repertoire.
DerSimonian H, Band H, Brenner MB. DerSimonian H, et al. J Exp Med. 1991 Sep 1;174(3):639-48. doi: 10.1084/jem.174.3.639. J Exp Med. 1991. PMID: 1678776 Free PMC article. - TCR V alpha- and V beta-gene segment use in T-cell subcultures derived from a type-III bare lymphocyte syndrome patient deficient in MHC class-II expression.
Lambert M, Van Eggermond M, Mascart F, Dupont E, Van den Elsen P. Lambert M, et al. Dev Immunol. 1992;2(3):227-36. doi: 10.1155/1992/29814. Dev Immunol. 1992. PMID: 1320968 Free PMC article. - On the organization of human T-cell receptor loci: log-periodic distribution of T-cell receptor gene segments.
Toor AA, Toor AA, Rahmani M, Manjili MH. Toor AA, et al. J R Soc Interface. 2016 Jan;13(114):20150911. doi: 10.1098/rsif.2015.0911. J R Soc Interface. 2016. PMID: 26763333 Free PMC article. Review.
Cited by
- Sex bias in MHC I-associated shaping of the adaptive immune system.
Schneider-Hohendorf T, Görlich D, Savola P, Kelkka T, Mustjoki S, Gross CC, Owens GC, Klotz L, Dornmair K, Wiendl H, Schwab N. Schneider-Hohendorf T, et al. Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2168-2173. doi: 10.1073/pnas.1716146115. Epub 2018 Feb 12. Proc Natl Acad Sci U S A. 2018. PMID: 29440397 Free PMC article. - Dietary gluten triggers concomitant activation of CD4+ and CD8+ αβ T cells and γδ T cells in celiac disease.
Han A, Newell EW, Glanville J, Fernandez-Becker N, Khosla C, Chien YH, Davis MM. Han A, et al. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13073-8. doi: 10.1073/pnas.1311861110. Epub 2013 Jul 22. Proc Natl Acad Sci U S A. 2013. PMID: 23878218 Free PMC article. Clinical Trial. - Mycobacterium bovis BCG scar status and HLA class II alleles influence purified protein derivative-specific T-cell receptor V beta expression in pulmonary tuberculosis patients from southern India.
Shanmugalakshmi S, Dheenadhayalan V, Muthuveeralakshmi P, Arivarignan G, Pitchappan RM. Shanmugalakshmi S, et al. Infect Immun. 2003 Aug;71(8):4544-53. doi: 10.1128/IAI.71.8.4544-4553.2003. Infect Immun. 2003. PMID: 12874334 Free PMC article. - Normalization of the peripheral blood T cell receptor V beta repertoire after cultured postnatal human thymic transplantation in DiGeorge syndrome.
Davis CM, McLaughlin TM, Watson TJ, Buckley RH, Schiff SE, Hale LP, Haynes BF, Markert ML. Davis CM, et al. J Clin Immunol. 1997 Mar;17(2):167-75. doi: 10.1023/a:1027382600143. J Clin Immunol. 1997. PMID: 9083893 - Changes in the peripheral blood T-Cell receptor V beta repertoire in vivo and in vitro during shigellosis.
Islam D, Wretlind B, Lindberg AA, Christensson B. Islam D, et al. Infect Immun. 1996 Apr;64(4):1391-9. doi: 10.1128/iai.64.4.1391-1399.1996. Infect Immun. 1996. PMID: 8606106 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials