Antibodies to the human 60 kDa heat-shock protein in patients with schizophrenia - PubMed (original) (raw)
Antibodies to the human 60 kDa heat-shock protein in patients with schizophrenia
K Kilidireas et al. Lancet. 1992.
Free article
Abstract
Immune mechanisms are thought to be important in a subpopulation of patients with schizophrenia. We examined the specificity of neural antibodies in patients with schizophrenia to identify a possible antigen. Serum antibodies from patients with schizophrenia and control subjects were tested for binding to protein extracts of human neuroblastoma cells by western blot. Protein antigens were characterised by aminoterminal and internal aminoacid sequence analysis. 14 of 32 (44%) otherwise healthy patients with schizophrenia had antibodies to a neuroblastoma protein of molecular weight 60 kDa. By partial sequence analysis, this protein was identified as the 60 kDa human heat-shock protein (hsp) that is the P1 mitochondrial protein, and which is 50% homologous to the mycobacterial 65 kDa hsp. Antigens that crossreact with hsp65 have been implicated in the pathogenesis of adjuvant-induced arthritis in rats and autoimmune diabetes in mice. Of 100 normal subjects or disease controls, antibodies to hsp60 were found in only 8 patients, all of whom had active infectious or inflammatory disease. Our results support the presence of abnormal immune reactivity involving hsp60 in a subset of patients with schizophrenia. The immune response may be related to the pathogenesis of the disease.
Similar articles
- Antibodies to neuroblastoma cell line proteins in patients with schizophrenia.
Mazeh D, Sirota P, Patya M, Novogrodsky A. Mazeh D, et al. J Neuroimmunol. 1998 Apr 15;84(2):218-22. doi: 10.1016/s0165-5728(97)00258-0. J Neuroimmunol. 1998. PMID: 9628466 - Antibody reactivity to mycobacterial 65 kDa heat shock protein: relevance to autoimmunity.
Karopoulos C, Rowley MJ, Handley CJ, Strugnell RA. Karopoulos C, et al. J Autoimmun. 1995 Apr;8(2):235-48. doi: 10.1006/jaut.1995.0018. J Autoimmun. 1995. PMID: 7542003 - Specificity of antibodies induced after immunization of mice with the mycobacterial heat shock protein of 65 kD.
Barrios C, Tougne C, Polla BS, Lambert PH, Del Giudice G. Barrios C, et al. Clin Exp Immunol. 1994 Nov;98(2):224-8. doi: 10.1111/j.1365-2249.1994.tb06129.x. Clin Exp Immunol. 1994. PMID: 7955526 Free PMC article. - Immunity to heat shock proteins in rheumatoid arthritis.
Lydyard PM, Tsoulfa G, Sharif M, Bröker B, Smith M, Rook GA. Lydyard PM, et al. Clin Exp Rheumatol. 1990 Jul-Aug;8 Suppl 5:69-74. Clin Exp Rheumatol. 1990. PMID: 2245530 Review. - The humoral immune response to heat shock proteins.
Mollenhauer J, Schulmeister A. Mollenhauer J, et al. Experientia. 1992 Jul 15;48(7):644-9. doi: 10.1007/BF02118310. Experientia. 1992. PMID: 1639172 Review.
Cited by
- Schizophrenia and Alarmins.
Ma H, Cheng N, Zhang C. Ma H, et al. Medicina (Kaunas). 2022 May 24;58(6):694. doi: 10.3390/medicina58060694. Medicina (Kaunas). 2022. PMID: 35743957 Free PMC article. Review. - Biomarkers in Child and Adolescent Depression.
Zwolińska W, Dmitrzak-Węglarz M, Słopień A. Zwolińska W, et al. Child Psychiatry Hum Dev. 2023 Feb;54(1):266-281. doi: 10.1007/s10578-021-01246-y. Epub 2021 Sep 29. Child Psychiatry Hum Dev. 2023. PMID: 34590201 Free PMC article. Review. - Genomic Variation, Evolvability, and the Paradox of Mental Illness.
Gualtieri CT. Gualtieri CT. Front Psychiatry. 2021 Jan 21;11:593233. doi: 10.3389/fpsyt.2020.593233. eCollection 2020. Front Psychiatry. 2021. PMID: 33551865 Free PMC article. - Brain antibodies in the cortex and blood of people with schizophrenia and controls.
Glass LJ, Sinclair D, Boerrigter D, Naude K, Fung SJ, Brown D, Catts VS, Tooney P, O'Donnell M, Lenroot R, Galletly C, Liu D, Weickert TW, Shannon Weickert C. Glass LJ, et al. Transl Psychiatry. 2017 Aug 8;7(8):e1192. doi: 10.1038/tp.2017.134. Transl Psychiatry. 2017. PMID: 28786974 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous