Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages - PubMed (original) (raw)
. 1992 Nov 19;360(6401):225-31.
doi: 10.1038/360225a0.
Affiliations
- PMID: 1359428
- DOI: 10.1038/360225a0
Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages
P Mombaerts et al. Nature. 1992.
Erratum in
- Nature 1992 Dec 3;360(6403):491
Abstract
Analysis of mice carrying mutant T-cell antigen receptor (TCR) genes indicates that TCR-beta gene rearrangement or expression is critical for the differentiation of CD4-CD8- thymocytes to CD4+CD8+ thymocytes, as well as for the expansion of the pool of CD4+CD8+ cells. TCR-alpha is irrelevant in these developmental processes. The development of gamma delta T cells does not depend on either TCR-alpha or TCR-beta.
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