Inhibition of specific pathways of myeloid cell differentiation by an activated Hox-2.4 homeobox gene - PubMed (original) (raw)
Affiliations
- PMID: 1359901
Inhibition of specific pathways of myeloid cell differentiation by an activated Hox-2.4 homeobox gene
C Blatt et al. Cell Growth Differ. 1992 Oct.
Abstract
Abnormal expression of homeobox genes is one of the abnormalities associated with the development of murine and human leukemia. Myeloid leukemic cells that can be induced to differentiate to mature cells by interleukin 6 were stably transfected with an activated Hox-2.4 homeobox gene. Expression of the Hox-2.4 gene in the transfected clones inhibited specific pathways of the myeloid differentiation program induced by interleukin 6. The expression of some genes associated with differentiation was almost completely blocked, and the expression of other genes was either partially inhibited or not affected. The results support the hypothesis that abnormal expression of Hox-2.4 may contribute to the development of leukemia by interfering with the differentiation program.
Similar articles
- Regulation of bcl-2, bcl-XL and bax in the control of apoptosis by hematopoietic cytokines and dexamethasone.
Lotem J, Sachs L. Lotem J, et al. Cell Growth Differ. 1995 Jun;6(6):647-53. Cell Growth Differ. 1995. PMID: 7669718 - Redundant functions of B-Myb and c-Myb in differentiating myeloid cells.
Golay J, Broccoli V, Borleri GM, Erba E, Faretta M, Basilico L, Ying GG, Piccinini G, Shapiro LH, Lovrić J, Nawrath M, Mölling K, Rambaldi A, Introna M. Golay J, et al. Cell Growth Differ. 1997 Dec;8(12):1305-16. Cell Growth Differ. 1997. PMID: 9419419 - HOX and non-HOX homeobox genes in leukemic hematopoiesis.
Owens BM, Hawley RG. Owens BM, et al. Stem Cells. 2002;20(5):364-79. doi: 10.1634/stemcells.20-5-364. Stem Cells. 2002. PMID: 12351808 Review. - Homeobox genes in hematopoiesis and leukemogenesis.
Shimamoto T, Ohyashiki K, Toyama K, Takeshita K. Shimamoto T, et al. Int J Hematol. 1998 Jun;67(4):339-50. doi: 10.1016/s0925-5710(98)00024-3. Int J Hematol. 1998. PMID: 9695407 Review.
Cited by
- HOXC4, HOXC5, and HOXC6 expression in primary cutaneous lymphoid lesions. High expression of HOXC5 in anaplastic large-cell lymphomas.
Bijl JJ, Rieger E, van Oostveen JW, Walboomers JM, Kreike M, Willemze R, Meijer CJ. Bijl JJ, et al. Am J Pathol. 1997 Oct;151(4):1067-74. Am J Pathol. 1997. PMID: 9327740 Free PMC article. - The control of hematopoiesis and leukemia: from basic biology to the clinic.
Sachs L. Sachs L. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4742-9. doi: 10.1073/pnas.93.10.4742. Proc Natl Acad Sci U S A. 1996. PMID: 8643473 Free PMC article. Review. - Transcriptional regulation during myelopoiesis.
Lenny N, Westendorf JJ, Hiebert SW. Lenny N, et al. Mol Biol Rep. 1997 Aug;24(3):157-68. doi: 10.1023/a:1006859700409. Mol Biol Rep. 1997. PMID: 9291089 Review. - The metabolic regulator mTORC1 controls terminal myeloid differentiation.
Lee PY, Sykes DB, Ameri S, Kalaitzidis D, Charles JF, Nelson-Maney N, Wei K, Cunin P, Morris A, Cardona AE, Root DE, Scadden DT, Nigrovic PA. Lee PY, et al. Sci Immunol. 2017 May 26;2(11):eaam6641. doi: 10.1126/sciimmunol.aam6641. Sci Immunol. 2017. PMID: 28763796 Free PMC article. - Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene.
Perkins AC, Cory S. Perkins AC, et al. EMBO J. 1993 Oct;12(10):3835-46. doi: 10.1002/j.1460-2075.1993.tb06062.x. EMBO J. 1993. PMID: 8104786 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Research Materials