Enzymatic formation of psychotomimetic metabolites from normally occurring compounds - PubMed (original) (raw)
Enzymatic formation of psychotomimetic metabolites from normally occurring compounds
J AXELROD. Science. 1961.
Abstract
An enzyme has been found that N-methylates serotonin and tryptamine to psychotomimetic metabolites, bufotenine and N,N-dimethyltryptamine. This enzyme is highly localized in the rabbit lung and also N-methylates phenylethylamine derivatives such as tyramine, phenylethylamine , mescaline, and dopamine.
Similar articles
- Further studies on the mode of action of psychotomimetic drugs: antagonism of the excitatory actions of 5-hydroxytryptamine by methylated derivatives of tryptamine.
Bradley PB, Briggs I. Bradley PB, et al. Br J Pharmacol. 1974 Mar;50(3):345-54. doi: 10.1111/j.1476-5381.1974.tb09609.x. Br J Pharmacol. 1974. PMID: 4277490 Free PMC article. - A possible mechanism for the antischizophrenic action of chlorpromazine: inhibition of the formation of dimethyltryptamine by chlorpromazine metabolites.
Narasimhachari N, Lin RL. Narasimhachari N, et al. Res Commun Chem Pathol Pharmacol. 1974 Jun;8(2):341-51. Res Commun Chem Pathol Pharmacol. 1974. PMID: 4527612 No abstract available. - A review of recent studies of the biosynthesis and excretion of hallucinogens formed by methylation of neurotransmitters or related substances.
Rosengarten H, Friedhoff AJ. Rosengarten H, et al. Schizophr Bull. 1976;2(1):90-105. doi: 10.1093/schbul/2.1.90. Schizophr Bull. 1976. PMID: 779022 Review. No abstract available. - N, N-dimethyltryptamine: an endogenous hallucinogen.
Barker SA, Monti JA, Christian ST. Barker SA, et al. Int Rev Neurobiol. 1981;22:83-110. doi: 10.1016/s0074-7742(08)60291-3. Int Rev Neurobiol. 1981. PMID: 6792104 Review. No abstract available. - N,N-dimethyltryptamine--a possible relationship to schizophrenia?
Wyatt RJ, Gillin JC, Kaplan J, Stillman R, Mandel L, Ahn HS, VandenHeuvel WJ, Walker RW. Wyatt RJ, et al. Adv Biochem Psychopharmacol. 1974;11(0):299-313. Adv Biochem Psychopharmacol. 1974. PMID: 4602668 Review. No abstract available.
Cited by
- Why N,N-dimethyltryptamine matters: unique features and therapeutic potential beyond classical psychedelics.
Chaves C, Dos Santos RG, Dursun SM, Tusconi M, Carta MG, Brietzke E, Hallak JEC. Chaves C, et al. Front Psychiatry. 2024 Nov 6;15:1485337. doi: 10.3389/fpsyt.2024.1485337. eCollection 2024. Front Psychiatry. 2024. PMID: 39568756 Free PMC article. - Neurobiological research on N,N-dimethyltryptamine (DMT) and its potentiation by monoamine oxidase (MAO) inhibition: from ayahuasca to synthetic combinations of DMT and MAO inhibitors.
Egger K, Aicher HD, Cumming P, Scheidegger M. Egger K, et al. Cell Mol Life Sci. 2024 Sep 10;81(1):395. doi: 10.1007/s00018-024-05353-6. Cell Mol Life Sci. 2024. PMID: 39254764 Free PMC article. Review. - Insights into S-adenosyl-l-methionine (SAM)-dependent methyltransferase related diseases and genetic polymorphisms.
Li J, Sun C, Cai W, Li J, Rosen BP, Chen J. Li J, et al. Mutat Res Rev Mutat Res. 2021 Jul-Dec;788:108396. doi: 10.1016/j.mrrev.2021.108396. Epub 2021 Oct 7. Mutat Res Rev Mutat Res. 2021. PMID: 34893161 Free PMC article. Review. - Molecular and Functional Imaging Studies of Psychedelic Drug Action in Animals and Humans.
Cumming P, Scheidegger M, Dornbierer D, Palner M, Quednow BB, Martin-Soelch C. Cumming P, et al. Molecules. 2021 Apr 22;26(9):2451. doi: 10.3390/molecules26092451. Molecules. 2021. PMID: 33922330 Free PMC article. Review. - Biosynthesis and synthetic biology of psychoactive natural products.
Jamieson CS, Misa J, Tang Y, Billingsley JM. Jamieson CS, et al. Chem Soc Rev. 2021 Jun 21;50(12):6950-7008. doi: 10.1039/d1cs00065a. Chem Soc Rev. 2021. PMID: 33908526 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources