Detection and localization of Epstein-Barr viral genomes in angioimmunoblastic lymphadenopathy and angioimmunoblastic lymphadenopathy-like lymphoma - PubMed (original) (raw)
. 1992 Apr 1;79(7):1789-95.
Affiliations
- PMID: 1373088
Free article
Detection and localization of Epstein-Barr viral genomes in angioimmunoblastic lymphadenopathy and angioimmunoblastic lymphadenopathy-like lymphoma
L M Weiss et al. Blood. 1992.
Free article
Abstract
We studied 23 cases of angioimmunoblastic lymphadenopathy (AILD) and AILD-like lymphoma for evidence of Epstein-Barr virus (EBV) using the polymerase chain reaction (PCR) and in situ hybridization studies. EBV nucleic acid sequences were found by either PCR or in situ hybridization in 96% of the cases. There was a wide range in the number of EBV-positive cells among the different cases as detected by in situ hybridization. The EBV-positive cells most often possessed nuclei of intermediate to large size. Double-labeling immunohistochemistry/in situ hybridization studies demonstrated that most of the EBV-positive cells expressed the B-lineage antigen CD20 (as detected by L26), with a minority of the EBV-positive cells stained for the T-lineage associated antigen, CD43 (as detected by Leu 22). The abnormally high amounts of EBV found in AILD and AILD-like lymphoma may be a reflection of decreased immunocompetence in these patients. The presence of EBV-positive B cells may explain the presence of B-cell clones found by others as well as the paradoxical occurrence of B-cell lymphoma in a primary T-cell lymphoproliferative disorder.
Similar articles
- Cutaneous involvement by angioimmunoblastic T-cell lymphoma with remarkable heterogeneous Epstein-Barr virus expression.
Brown HA, Macon WR, Kurtin PJ, Gibson LE. Brown HA, et al. J Cutan Pathol. 2001 Sep;28(8):432-8. doi: 10.1034/j.1600-0560.2001.028008432.x. J Cutan Pathol. 2001. PMID: 11493382 - B-cell lymphoma after angioimmunoblastic lymphadenopathy: a case with oligoclonal gene rearrangements associated with Epstein-Barr virus.
Abruzzo LV, Schmidt K, Weiss LM, Jaffe ES, Medeiros LJ, Sander CA, Raffeld M. Abruzzo LV, et al. Blood. 1993 Jul 1;82(1):241-6. Blood. 1993. PMID: 8391875 - Heterogeneity of Epstein-Barr virus infection in angioimmunoblastic lymphadenopathy type T-cell lymphoma.
Ohshima K, Takeo H, Kikuchi M, Kozuru M, Uike N, Masuda Y, Yoneda S, Takeshita M, Shibata T, Akamatsu M. Ohshima K, et al. Histopathology. 1994 Dec;25(6):569-79. doi: 10.1111/j.1365-2559.1994.tb01376.x. Histopathology. 1994. PMID: 7698734 - [Heterogeneous Epstein-Barr virus infection patterns in peripheral T cell lymphoma of the angioimmunoblastic lymphadenopathy type].
Anagnostopoulos I, Hummel M, Finn T, Tiemann M, Dimmler C, Korbjuhn P, Dallenbach F, Niedobitek G, Gatter K, Parwaresch MR, et al. Anagnostopoulos I, et al. Verh Dtsch Ges Pathol. 1992;76:202-6. Verh Dtsch Ges Pathol. 1992. PMID: 1283259 German. - Significance of the detection of Epstein-Barr virus DNA in lymph nodes in patients with Hodgkin's disease.
Knecht H, Joske DJ, Bachmann E, Sahli R, Odermatt BF. Knecht H, et al. Leuk Lymphoma. 1992 Nov;8(4-5):319-25. doi: 10.3109/10428199209051010. Leuk Lymphoma. 1992. PMID: 1337849 Review.
Cited by
- Atypical lymphoplasmacytic and immunoblastic proliferation: A Systematic Review.
Nishimura MF, Takahashi T, Takaoka K, Macapagal S, Wannaphut C, Nishikori A, Toda H, Nishimura Y, Sato Y. Nishimura MF, et al. J Clin Exp Hematop. 2024;64(2):97-106. doi: 10.3960/jslrt.24007. J Clin Exp Hematop. 2024. PMID: 38925977 Free PMC article. - Contribution of the Epstein-Barr virus to the oncogenesis of mature T-cell lymphoproliferative neoplasms.
Barros MHM, Alves PDS. Barros MHM, et al. Front Oncol. 2023 Sep 14;13:1240359. doi: 10.3389/fonc.2023.1240359. eCollection 2023. Front Oncol. 2023. PMID: 37781191 Free PMC article. Review. - Fas/FasL and Complement Activation are Associated with Chronic Active Epstein-Barr Virus Hepatitis.
Lin J, Su MF, Zheng JL, Gu L, Wu HC, Wu X, Lin HY, Wu ZX, Li DL. Lin J, et al. J Clin Transl Hepatol. 2023 Jun 28;11(3):540-549. doi: 10.14218/JCTH.2022.00227. Epub 2022 Sep 14. J Clin Transl Hepatol. 2023. PMID: 36969885 Free PMC article. - Angioimmunoblastic T-cell lymphoma induced hemophagocytic lymphohistiocytosis and disseminated intravascular coagulopathy: A case report.
Jiang M, Wan JH, Tu Y, Shen Y, Kong FC, Zhang ZL. Jiang M, et al. World J Clin Cases. 2023 Feb 16;11(5):1086-1093. doi: 10.12998/wjcc.v11.i5.1086. World J Clin Cases. 2023. PMID: 36874426 Free PMC article. - Pathological and Molecular Features of Nodal Peripheral T-Cell Lymphomas.
Satou A, Takahara T, Tsuzuki T. Satou A, et al. Diagnostics (Basel). 2022 Aug 18;12(8):2001. doi: 10.3390/diagnostics12082001. Diagnostics (Basel). 2022. PMID: 36010351 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical