Among naive precursor cell subpopulations only progenitors of memory B cells originate germinal centers - PubMed (original) (raw)
Among naive precursor cell subpopulations only progenitors of memory B cells originate germinal centers
P J Linton et al. Eur J Immunol. 1992 May.
Abstract
Immunization leads to the generation of both antibody-forming cells (AFC) and memory B cells which are thought to arise in germinal centers within lymphoid follicles. The findings that the precursors to memory B cells reside in the J11Dlo subpopulation of the spleens in non-immune mice and that this subpopulation is distinct from conventional AFC precursors, including CD5+ B cells, suggest that the precursors of germinal centers might also reside in the J11Dlo subpopulation. To test this hypothesis, SCID mice were repopulated with CD4+ carrier-primed T cells and T-depleted J11Dlo, J11Dhi or CD5+ B cells and immunized with a hapten-carrier conjugate. Only the J11Dlo population was enriched for cells that produced germinal centers. Thus, the subpopulation of precursors that generates memory B cells also originates germinal centers.
Similar articles
- The cellular origins of memory B cells.
Klinman NR. Klinman NR. Semin Immunol. 1997 Aug;9(4):241-7. doi: 10.1006/smim.1997.0075. Semin Immunol. 1997. PMID: 9237930 Review. - The generation of memory B cells.
Linton PJ, Klinman NR. Linton PJ, et al. Semin Immunol. 1992 Feb;4(1):3-9. Semin Immunol. 1992. PMID: 1591368 Review. - Human hematopoietic stem/progenitor cells generate CD5+ B lymphoid cells in NOD/SCID mice.
Novelli EM, Ramírez M, Leung W, Civin CI. Novelli EM, et al. Stem Cells. 1999;17(5):242-52. doi: 10.1002/stem.170242. Stem Cells. 1999. PMID: 10527459 - The xid mutation diminishes memory B cell generation but does not affect somatic hypermutation and selection.
Ridderstad A, Nossal GJ, Tarlinton DM. Ridderstad A, et al. J Immunol. 1996 Oct 15;157(8):3357-65. J Immunol. 1996. PMID: 8871632 - Surface phenotype of Peyer's patch germinal center cells: implications for the role of germinal centers in B cell differentiation.
Butcher EC, Rouse RV, Coffman RL, Nottenburg CN, Hardy RR, Weissman IL. Butcher EC, et al. J Immunol. 1982 Dec;129(6):2698-707. J Immunol. 1982. PMID: 6982940
Cited by
- CD5-positive and CD5-negative human B cells converge to an indistinguishable population on signalling through B-cell receptors and CD40.
Gagro A, McCloskey N, Challa A, Holder M, Grafton G, Pound JD, Gordon J. Gagro A, et al. Immunology. 2000 Oct;101(2):201-9. doi: 10.1046/j.1365-2567.2000.00098.x. Immunology. 2000. PMID: 11012773 Free PMC article. - Facultative role of germinal centers and T cells in the somatic diversification of IgVH genes.
Miller C, Stedra J, Kelsoe G, Cerny J. Miller C, et al. J Exp Med. 1995 Apr 1;181(4):1319-31. doi: 10.1084/jem.181.4.1319. J Exp Med. 1995. PMID: 7535332 Free PMC article. - Germinal center B cell initiation, GC maturation, and the coevolution of its stromal cell niches.
Haberman AM, Gonzalez DG, Wong P, Zhang TT, Kerfoot SM. Haberman AM, et al. Immunol Rev. 2019 Mar;288(1):10-27. doi: 10.1111/imr.12731. Immunol Rev. 2019. PMID: 30874342 Free PMC article. Review. - Immunoglobulin class switching appears to be regulated by B-cell antigen receptor-specific T-cell action.
Lange H, Hecht O, Zemlin M, Trad A, Tanasa RI, Schroeder HW Jr, Lemke H. Lange H, et al. Eur J Immunol. 2012 Apr;42(4):1016-29. doi: 10.1002/eji.201141857. Eur J Immunol. 2012. PMID: 22531925 Free PMC article. - Cellular choreography in the germinal center: new visions from in vivo imaging.
Hauser AE, Kerfoot SM, Haberman AM. Hauser AE, et al. Semin Immunopathol. 2010 Sep;32(3):239-55. doi: 10.1007/s00281-010-0214-z. Epub 2010 Jul 9. Semin Immunopathol. 2010. PMID: 20614218 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials