The mechanism of action of cyclosporin A and FK506 - PubMed (original) (raw)
Review
The mechanism of action of cyclosporin A and FK506
S L Schreiber et al. Immunol Today. 1992 Apr.
Abstract
CsA and FK506 are powerful suppressors of the immune system, most notably of T cells. They act at a point in activation that lies between receptor ligation and the transcription of early genes. Here, Stuart Schreiber and Gerald Crabtree review recent findings that indicate CsA and FK506 operate as prodrugs: they bind endogenous intracellular receptors, the immunophilins, and the resulting complex targets the protein phosphatase, calcineurin, to exert the immunosuppressive effect.
Similar articles
- Calcineurin mutants render T lymphocytes resistant to cyclosporin A.
Zhu D, Cardenas ME, Heitman J. Zhu D, et al. Mol Pharmacol. 1996 Sep;50(3):506-11. Mol Pharmacol. 1996. PMID: 8794888 - Molecular and biological actions of cyclosporin A and FK506 on T cell development and function.
Holländer GA, Bierer BE, Burakoff SJ. Holländer GA, et al. Transfus Sci. 1994 Sep;15(3):207-20. doi: 10.1016/0955-3886(94)90133-3. Transfus Sci. 1994. PMID: 10155542 Review. - Superior T-cell suppression by rapamycin and FK506 over rapamycin and cyclosporine A because of abrogated cytotoxic T-lymphocyte induction, impaired memory responses, and persistent apoptosis.
Koenen HJ, Michielsen EC, Verstappen J, Fasse E, Joosten I. Koenen HJ, et al. Transplantation. 2003 May 15;75(9):1581-90. doi: 10.1097/01.TP.0000053752.87383.67. Transplantation. 2003. PMID: 12792519 - Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation.
Clipstone NA, Crabtree GR. Clipstone NA, et al. Nature. 1992 Jun 25;357(6380):695-7. doi: 10.1038/357695a0. Nature. 1992. PMID: 1377362 - The mechanism of action of cyclosporin A and FK506.
Ho S, Clipstone N, Timmermann L, Northrop J, Graef I, Fiorentino D, Nourse J, Crabtree GR. Ho S, et al. Clin Immunol Immunopathol. 1996 Sep;80(3 Pt 2):S40-5. doi: 10.1006/clin.1996.0140. Clin Immunol Immunopathol. 1996. PMID: 8811062 Review.
Cited by
- Low-Voltage-Activated CaV3.1 Calcium Channels Shape T Helper Cell Cytokine Profiles.
Wang H, Zhang X, Xue L, Xing J, Jouvin MH, Putney JW, Anderson MP, Trebak M, Kinet JP. Wang H, et al. Immunity. 2016 Apr 19;44(4):782-94. doi: 10.1016/j.immuni.2016.01.015. Epub 2016 Mar 29. Immunity. 2016. PMID: 27037192 Free PMC article. - Modified tectonic corneoscleral graft technique for treating devastating corneoscleral infections.
Zhang X, Qi X, Lu X, Gao H. Zhang X, et al. BMC Ophthalmol. 2024 Sep 11;24(1):402. doi: 10.1186/s12886-024-03669-2. BMC Ophthalmol. 2024. PMID: 39261792 Free PMC article. - Development of a robust method for establishing B cell lines using Epstein-Barr Virus.
Danjoh I, Sone H, Shirota R, Hiroyama T, Nakamura Y. Danjoh I, et al. In Vitro Cell Dev Biol Anim. 2012 Aug;48(7):393-402. doi: 10.1007/s11626-012-9523-y. Epub 2012 Jul 18. In Vitro Cell Dev Biol Anim. 2012. PMID: 22806969 - Assaying macrophage activity in a murine model of inflammatory bowel disease using fluorine-19 MRI.
Kadayakkara DK, Ranganathan S, Young WB, Ahrens ET. Kadayakkara DK, et al. Lab Invest. 2012 Apr;92(4):636-45. doi: 10.1038/labinvest.2012.7. Epub 2012 Feb 13. Lab Invest. 2012. PMID: 22330343 Free PMC article. - Neuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity.
Fields JA, Overk C, Adame A, Florio J, Mante M, Pineda A, Desplats P, Rockenstein E, Achim C, Masliah E. Fields JA, et al. J Neuroinflammation. 2016 May 24;13(1):120. doi: 10.1186/s12974-016-0585-8. J Neuroinflammation. 2016. PMID: 27220536 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources