Molecular diversity of the NMDA receptor channel - PubMed (original) (raw)

Comparative Study

. 1992 Jul 2;358(6381):36-41.

doi: 10.1038/358036a0.

Affiliations

• PMID: 1377365
• DOI: 10.1038/358036a0

Comparative Study

Molecular diversity of the NMDA receptor channel

T Kutsuwada et al. Nature. 1992.

Abstract

Two novel subunits of the mouse NMDA receptor channel, the epsilon 2 and epsilon 3 subunits, have been identified by cloning and expression of complementary DNAs. The heteromeric epsilon 1/zeta 1, epsilon 2/zeta 1 and epsilon 3/zeta 1 NMDA receptor channels exhibit distinct functional properties in affinities for agonists and sensitivities to competitive antagonists and Mg2+ block. In contrast to the wide distribution of the epsilon 1 and zeta 1 subunit messenger RNAs in the brain, the epsilon 2 subunit mRNA is expressed only in the forebrain and the epsilon 3 subunit mRNA is found predominantly in the cerebellum. The epsilon 1/zeta 1 and epsilon 2/zeta 1 channels expressed in Xenopus oocytes, but not the epsilon 3/zeta 1 channel, are activated by treatment with 12-O-tetradecanoylphorbol 13-acetate. These findings suggest that the molecular diversity of the epsilon subunit family underlies the functional heterogeneity of the NMDA receptor channel.

PubMed Disclaimer

Comment in

• NMDA receptors. On to molecular mechanisms.
  Stevens CF. Stevens CF. Nature. 1992 Jul 2;358(6381):18-9. doi: 10.1038/358018a0. Nature. 1992. PMID: 1535421 No abstract available.

Similar articles

• Differential ethanol sensitivity of recombinant N-methyl-D-aspartate receptor subunits.
  Masood K, Wu C, Brauneis U, Weight FF. Masood K, et al. Mol Pharmacol. 1994 Feb;45(2):324-9. Mol Pharmacol. 1994. PMID: 8114679
• Phosphorylation of the carboxyl-terminal domain of the zeta 1 subunit is not responsible for potentiation by TPA of the NMDA receptor channel.
  Yamakura T, Mori H, Shimoji K, Mishina M. Yamakura T, et al. Biochem Biophys Res Commun. 1993 Nov 15;196(3):1537-44. doi: 10.1006/bbrc.1993.2426. Biochem Biophys Res Commun. 1993. PMID: 7504480
• Identification by mutagenesis of a Mg(2+)-block site of the NMDA receptor channel.
  Mori H, Masaki H, Yamakura T, Mishina M. Mori H, et al. Nature. 1992 Aug 20;358(6388):673-5. doi: 10.1038/358673a0. Nature. 1992. PMID: 1386653
• Molecular and functional diversity of the NMDA receptor channel.
  Mishina M, Mori H, Araki K, Kushiya E, Meguro H, Kutsuwada T, Kashiwabuchi N, Ikeda K, Nagasawa M, Yamazaki M, et al. Mishina M, et al. Ann N Y Acad Sci. 1993 Dec 20;707:136-52. doi: 10.1111/j.1749-6632.1993.tb38049.x. Ann N Y Acad Sci. 1993. PMID: 9137549 Review. No abstract available.

Cited by

• Schizophrenia: redox regulation and volume neurotransmission.
  Bókkon I, Antal I. Bókkon I, et al. Curr Neuropharmacol. 2011 Jun;9(2):289-300. doi: 10.2174/157015911795596504. Curr Neuropharmacol. 2011. PMID: 22131938 Free PMC article.
• Transcriptome profiling of hippocampal CA1 after early-life seizure-induced preconditioning may elucidate new genetic therapies for epilepsy.
  Friedman LK, Mancuso J, Patel A, Kudur V, Leheste JR, Iacobas S, Botta J, Iacobas DA, Spray DC. Friedman LK, et al. Eur J Neurosci. 2013 Jul;38(1):2139-52. doi: 10.1111/ejn.12168. Epub 2013 Apr 4. Eur J Neurosci. 2013. PMID: 23551718 Free PMC article.
• NMDA receptor GluRepsilon/NR2 subunits are essential for postsynaptic localization and protein stability of GluRzeta1/NR1 subunit.
  Abe M, Fukaya M, Yagi T, Mishina M, Watanabe M, Sakimura K. Abe M, et al. J Neurosci. 2004 Aug 18;24(33):7292-304. doi: 10.1523/JNEUROSCI.1261-04.2004. J Neurosci. 2004. PMID: 15317856 Free PMC article.
• Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour.
  Taniguchi S, Nakazawa T, Tanimura A, Kiyama Y, Tezuka T, Watabe AM, Katayama N, Yokoyama K, Inoue T, Izumi-Nakaseko H, Kakuta S, Sudo K, Iwakura Y, Umemori H, Inoue T, Murphy NP, Hashimoto K, Kano M, Manabe T, Yamamoto T. Taniguchi S, et al. EMBO J. 2009 Dec 2;28(23):3717-29. doi: 10.1038/emboj.2009.300. Epub 2009 Oct 15. EMBO J. 2009. PMID: 19834457 Free PMC article.
• Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes.
  Chen PE, Geballe MT, Katz E, Erreger K, Livesey MR, O'Toole KK, Le P, Lee CJ, Snyder JP, Traynelis SF, Wyllie DJ. Chen PE, et al. J Physiol. 2008 Jan 1;586(1):227-45. doi: 10.1113/jphysiol.2007.143172. Epub 2007 Oct 25. J Physiol. 2008. PMID: 17962328 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • BioCyc
  • Gene Ontology
  • GlyGen glycoinformatics resource
  • Mouse Genome Informatics (MGI)