The role of angiogenesis in tumor growth - PubMed (original) (raw)
Affiliations
- PMID: 1378311
Review
The role of angiogenesis in tumor growth
J Folkman. Semin Cancer Biol. 1992 Apr.
Abstract
Experimental and clinical evidence is here assembled in support of the concept that the development of a solid tumor progresses from a prevascular phase to a vascular phase. The prevascular tumor does not induce angiogenesis, is limited in size, and rarely metastasizes. The vascularized tumor induces host microvessels to undergo angiogenesis, has the potential to rapidly expand its cell population, and has a propensity to metastasize. Thus, angiogenesis is necessary but not sufficient for tumor growth and metastasis. Neovascularization of a tumor requires that a critical number of its cells have switched to the angiogenic phenotype. The mechanisms by which tumor cells become angiogenic, subjects of current study, are reviewed here. At least two general categories are recognized: (i) angiogenic activity arises from the tumor cell itself in the form of the release of angiogenic molecules such as basic fibroblast growth factor; (ii) angiogenic activity arises from host cells recruited by the tumor (e.g. macrophages), or is mobilized from the extracellular matrix, or requires concomitant loss of physiological inhibition of endothelial cell proliferation. Accumulating evidence indicates that for most tumors, the switch to the angiogenic phenotype depends upon the outcome of a balance between angiogenic stimulators and angiogenic inhibitors, both of which may be produced by tumor cells and perhaps by certain host cells.
Similar articles
- The host support niche as a control point for tumor dormancy: implications for tumor development and beyond.
Hahnfeldt P. Hahnfeldt P. Adv Exp Med Biol. 2013;734:19-35. doi: 10.1007/978-1-4614-1445-2_2. Adv Exp Med Biol. 2013. PMID: 23143973 - [Angiogenesis and its regulation].
Iwaguchi T. Iwaguchi T. Gan To Kagaku Ryoho. 1993 Jan;20(1):1-9. Gan To Kagaku Ryoho. 1993. PMID: 7678486 Review. Japanese. - Mechanism and its regulation of tumor-induced angiogenesis.
Gupta MK, Qin RY. Gupta MK, et al. World J Gastroenterol. 2003 Jun;9(6):1144-55. doi: 10.3748/wjg.v9.i6.1144. World J Gastroenterol. 2003. PMID: 12800214 Free PMC article. Review. - Insights into the regulation of tumor dormancy by angiogenesis in experimental tumors.
Indraccolo S. Indraccolo S. Adv Exp Med Biol. 2013;734:37-52. doi: 10.1007/978-1-4614-1445-2_3. Adv Exp Med Biol. 2013. PMID: 23143974 - Circulating angiogenic growth factor levels in mice bearing human tumors using Luminex Multiplex technology.
Keyes KA, Mann L, Cox K, Treadway P, Iversen P, Chen YF, Teicher BA. Keyes KA, et al. Cancer Chemother Pharmacol. 2003 Apr;51(4):321-7. doi: 10.1007/s00280-003-0572-5. Epub 2003 Mar 18. Cancer Chemother Pharmacol. 2003. PMID: 12721760
Cited by
- A Deep Learning-Based Framework for Highly Accelerated Prostate MR Dispersion Imaging.
Zhao K, Pang K, Hung AL, Zheng H, Yan R, Sung K. Zhao K, et al. Cancers (Basel). 2024 Aug 27;16(17):2983. doi: 10.3390/cancers16172983. Cancers (Basel). 2024. PMID: 39272841 Free PMC article. - Investigation of breast cancer molecular subtype in a multi-ethnic population using MRI.
Ab Mumin N, Ramli Hamid MT, Wong JHD, Chiew SF, Rahmat K, Ng KH. Ab Mumin N, et al. PLoS One. 2024 Aug 29;19(8):e0309131. doi: 10.1371/journal.pone.0309131. eCollection 2024. PLoS One. 2024. PMID: 39208284 Free PMC article. - mir-744-5p inhibits cell growth and angiogenesis in osteosarcoma by targeting NFIX.
Xie L, Li W, Li Y. Xie L, et al. J Orthop Surg Res. 2024 Aug 17;19(1):485. doi: 10.1186/s13018-024-04947-x. J Orthop Surg Res. 2024. PMID: 39152460 Free PMC article. - Role of Permeability Surface Area Product in Grading of Brain Gliomas using CT Perfusion.
Agrawal I, Bano S, Chaudhary A, Ahuja A. Agrawal I, et al. Asian J Neurosurg. 2023 Nov 7;18(4):751-760. doi: 10.1055/s-0043-1774820. eCollection 2023 Dec. Asian J Neurosurg. 2023. PMID: 38161609 Free PMC article. - Image-based modeling of vascular organization to evaluate anti-angiogenic therapy.
Ascheid D, Baumann M, Funke C, Volz J, Pinnecker J, Friedrich M, Höhn M, Nandigama R, Ergün S, Nieswandt B, Heinze KG, Henke E. Ascheid D, et al. Biol Direct. 2023 Mar 15;18(1):10. doi: 10.1186/s13062-023-00365-x. Biol Direct. 2023. PMID: 36922848 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources