Immune regulation by brain cells in the central nervous system: microglia but not astrocytes present myelin basic protein to encephalitogenic T cells under in vivo-mimicking conditions - PubMed (original) (raw)

Immune regulation by brain cells in the central nervous system: microglia but not astrocytes present myelin basic protein to encephalitogenic T cells under in vivo-mimicking conditions

Y Matsumoto et al. Immunology. 1992 Jun.

Abstract

The antigen-presenting capability of various types of brain cell, such as primary mixed glial cells, astrocytes and microglia, was examined under conditions in which Ia antigen expression on the cultured cells mimicked that in the central nervous system (CNS) of rats with experimental autoimmune encephalomyelitis (EAE). In the CNS of rats with EAE, microglia but not astrocytes express Ia antigens. To produce such conditions, cultured brain cells were treated with various concentrations of interferon-gamma (IFN-gamma). It was revealed that in vivo-like conditions were produced when cultured brain cells were treated with less than 100 U/ml IFN-gamma. Under such conditions, microglia presented an antigen, myelin basic protein (MBP), to MBP-specific T-cell lines. Astrocytes, on the other hand, did not show antigen-presenting ability, but rather suppressed T-cell proliferation. Primary mixed glial cells, mainly comprising astrocytes and microglia, were also weak antigen-presenting cells (APC). These findings suggest that brain cells comprising various types of cell with regard to APC function do not up-regulate the proliferation of encephalitogenic T cells in vivo, although a particular type of brain cell, i.e. microglia, show antigen-presenting capability.

PubMed Disclaimer

Cited by

In situ inactivation of infiltrating T cells in the central nervous system with autoimmune encephalomyelitis. The role of astrocytes.
Matsumoto Y, Hanawa H, Tsuchida M, Abo T. Matsumoto Y, et al. Immunology. 1993 Jul;79(3):381-90. Immunology. 1993. PMID: 7691723 Free PMC article.
Precursors of Borna disease virus-specific T cells in secondary lymphatic tissue of experimentally infected rats.
Batra A, Planz O, Bilzer T, Stitz L. Batra A, et al. J Neurovirol. 2003 Jun;9(3):325-35. doi: 10.1080/13550280390201038. J Neurovirol. 2003. PMID: 12775416
Induction of MHC class II antigens on rat bronchial epithelial cells by interferon-gamma and its effect on antigen presentation.
Suda T, Sato A, Sugiura W, Chida K. Suda T, et al. Lung. 1995;173(2):127-37. doi: 10.1007/BF02981472. Lung. 1995. PMID: 7715254
Anatomical and cellular requirements for the activation and migration of virus-specific CD8+ T cells to the brain during Theiler's virus infection.
Mendez-Fernandez YV, Hansen MJ, Rodriguez M, Pease LR. Mendez-Fernandez YV, et al. J Virol. 2005 Mar;79(5):3063-70. doi: 10.1128/JVI.79.5.3063-3070.2005. J Virol. 2005. PMID: 15709026 Free PMC article.
Cervical lymphoid tissue but not the central nervous system supports proliferation of virus-specific T lymphocytes during coronavirus-induced encephalitis in rats.
Imrich H, Schwender S, Hein A, Dörries R. Imrich H, et al. J Neuroimmunol. 1994 Aug;53(1):73-81. doi: 10.1016/0165-5728(94)90066-3. J Neuroimmunol. 1994. PMID: 7914212 Free PMC article.

References

1. Eur J Immunol. 1990 Jan;20(1):195-200 - PubMed
1. Neurosci Lett. 1983 Oct 31;41(1-2):199-204 - PubMed
1. Eur J Immunol. 1990 Sep;20(9):2119-26 - PubMed
1. Am J Pathol. 1990 Oct;137(4):789-800 - PubMed
1. J Immunol. 1988 Oct 1;141(7):2216-20 - PubMed

Immune regulation by brain cells in the central nervous system: microglia but not astrocytes present myelin basic protein to encephalitogenic T cells under in vivo-mimicking conditions - PubMed (original) (raw)