Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase - PubMed (original) (raw)
. 1992 Sep 18;257(5077):1685-9.
doi: 10.1126/science.1382315.
Affiliations
- PMID: 1382315
- DOI: 10.1126/science.1382315
Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase
A E Koromilas et al. Science. 1992.
Abstract
The double-stranded RNA-dependent protein kinase (dsRNA-PK) is thought to be a key mediator of the antiviral and antiproliferative effects of interferons (IFNs). Studies examining the physiological function of the kinase suggest that it participates in cell growth and differentiation by regulating protein synthesis. Autophosphorylation and consequent activation of dsRNA-PK in vitro and in vivo result in phosphorylation of the alpha subunit of eukaryotic initiation factor-2 (eIF-2) and inhibition of protein synthesis. Expression of a functionally defective mutant of human dsRNA-PK in NIH 3T3 cells resulted in malignant transformation, suggesting that dsRNA-PK may function as a suppressor of cell proliferation and tumorigenesis.
Similar articles
- Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase.
Meurs EF, Galabru J, Barber GN, Katze MG, Hovanessian AG. Meurs EF, et al. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):232-6. doi: 10.1073/pnas.90.1.232. Proc Natl Acad Sci U S A. 1993. PMID: 7678339 Free PMC article. - Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon.
Meurs E, Chong K, Galabru J, Thomas NS, Kerr IM, Williams BR, Hovanessian AG. Meurs E, et al. Cell. 1990 Jul 27;62(2):379-90. doi: 10.1016/0092-8674(90)90374-n. Cell. 1990. PMID: 1695551 - Interferon-induced and double-stranded RNA-activated enzymes: a specific protein kinase and 2',5'-oligoadenylate synthetases.
Hovanessian AG. Hovanessian AG. J Interferon Res. 1991 Aug;11(4):199-205. doi: 10.1089/jir.1991.11.199. J Interferon Res. 1991. PMID: 1717615 Review. - The double stranded RNA-activated protein kinase induced by interferon: dsRNA-PK.
Hovanessian AG. Hovanessian AG. J Interferon Res. 1989 Dec;9(6):641-7. doi: 10.1089/jir.1989.9.641. J Interferon Res. 1989. PMID: 2481698 Review. No abstract available.
Cited by
- A helical fulcrum in eIF2B coordinates allosteric regulation of stress signaling.
Lawrence RE, Shoemaker SR, Deal A, Sangwan S, Anand AA, Wang L, Marqusee S, Walter P. Lawrence RE, et al. Nat Chem Biol. 2024 Apr;20(4):422-431. doi: 10.1038/s41589-023-01453-9. Epub 2023 Nov 9. Nat Chem Biol. 2024. PMID: 37945896 Free PMC article. - Selective inhibition of PKR by C16 accelerates diabetic wound healing by inhibiting NALP3 expression in mice.
Karnam K, Sedmaki K, Sharma P, Venuganti VVK, Kulkarni OP. Karnam K, et al. Inflamm Res. 2023 Feb;72(2):221-236. doi: 10.1007/s00011-022-01667-y. Epub 2022 Nov 23. Inflamm Res. 2023. PMID: 36418464 - A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation.
Boone M, Wang L, Lawrence RE, Frost A, Walter P, Schoof M. Boone M, et al. Elife. 2022 Apr 13;11:e76171. doi: 10.7554/eLife.76171. Elife. 2022. PMID: 35416150 Free PMC article. - Novel Molecular Basis for Synapse Formation: Small Non-coding Vault RNA Functions as a Riboregulator of MEK1 to Modulate Synaptogenesis.
Wakatsuki S, Araki T. Wakatsuki S, et al. Front Mol Neurosci. 2021 Sep 24;14:748721. doi: 10.3389/fnmol.2021.748721. eCollection 2021. Front Mol Neurosci. 2021. PMID: 34630040 Free PMC article. - Poly(U)-specific endoribonuclease ENDOU promotes translation of human CHOP mRNA by releasing uORF element-mediated inhibition.
Lee HC, Fu CY, Lin CY, Hu JR, Huang TY, Lo KY, Tsai HY, Sheu JC, Tsai HJ. Lee HC, et al. EMBO J. 2021 Jun 1;40(11):e104123. doi: 10.15252/embj.2019104123. Epub 2021 Jan 28. EMBO J. 2021. PMID: 33511665 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources