Neurons and neuroblastoma as a source of macrophage colony-stimulating factor - PubMed (original) (raw)
. 1992 Oct;22(10):2539-45.
doi: 10.1002/eji.1830221012.
Affiliations
- PMID: 1396961
- DOI: 10.1002/eji.1830221012
Neurons and neuroblastoma as a source of macrophage colony-stimulating factor
K Nohava et al. Eur J Immunol. 1992 Oct.
Abstract
Accumulation of macrophages in brain tissue as observed in nervous system injury may be due to local production of hematopoietic colony-stimulating factors (CSF). The present work shows human neuroblastoma cells and murine neurons, namely granule cells of the cerebellum, to produce macrophage (M)-CSF which guides expansion and differentiation of macrophage lineage cells. The mRNA-encoding M-CSF but not the respective protein is present in mouse brain including cerebellum. Neither granulocyte M-CSF nor IL-3 is produced by cerebellar neurons or neuroblastoma. By their production of M-CSF, neurons may regulate the macrophage response and lead to local expansion and enhanced function of macrophages in inflammatory diseases of the central nervous system.
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