Immunohistochemical and biochemical analysis of N-cadherin expression during CNS development - PubMed (original) (raw)
Immunohistochemical and biochemical analysis of N-cadherin expression during CNS development
L A Lagunowich et al. J Neurosci Res. 1992 Jun.
Abstract
The expression of the calcium-dependent adhesion molecule N-cadherin during chick embryo central nervous system (CNS) development was examined by immunohistochemistry and electrophoresis and immunoblotting. During histogenesis, N-cadherin is expressed at high levels in a uniform fashion in many regions of the CNS. However, during later stages of development, expression becomes restricted to the ependymal cells lining the ventricular system and in the choroid plexus. This down-regulation was confirmed by both immunohistochemical and biochemical techniques. The program of expression lags behind in the cerebellum in concert with the delayed development of this region of the brain. A high level of N-cadherin was found to be expressed in the brainstem and spinal cord floorplate, while a low level was detected at the optic nerve head. The results indicate that while, in general, the program of N-cadherin expression is similar in the retina and the brain, certain structures unique to the eye and brain express locally high or low levels of this adhesion protein.
Similar articles
- Differential expression of N- and R-cadherin in functional neuronal systems and other structures of the developing chicken brain.
Redies C, Engelhart K, Takeichi M. Redies C, et al. J Comp Neurol. 1993 Jul 15;333(3):398-416. doi: 10.1002/cne.903330307. J Comp Neurol. 1993. PMID: 7688773 - N-cadherin in normal and abnormal brain development.
Lagunowich LA, Stein AP, Reuhl KR. Lagunowich LA, et al. Neurotoxicology. 1994 Spring;15(1):123-32. Neurotoxicology. 1994. PMID: 8090352 - Cadherin expression in the developing vertebrate CNS: from neuromeres to brain nuclei and neural circuits.
Redies C. Redies C. Exp Cell Res. 1995 Oct;220(2):243-56. doi: 10.1006/excr.1995.1313. Exp Cell Res. 1995. PMID: 7556431 Review. - Cadherins in the developing central nervous system: an adhesive code for segmental and functional subdivisions.
Redies C, Takeichi M. Redies C, et al. Dev Biol. 1996 Dec 15;180(2):413-23. doi: 10.1006/dbio.1996.0315. Dev Biol. 1996. PMID: 8954714 Review.
Cited by
- Developmental expression of KG-CAM in the rat neostriatum.
Kuga Y, Geisert EE Jr, Kono T, Yamamoto T, Kitai ST. Kuga Y, et al. Anat Embryol (Berl). 1995 Mar;191(3):191-201. doi: 10.1007/BF00187818. Anat Embryol (Berl). 1995. PMID: 7539603 - N-cadherin is regulated by gonadal steroids in the adult hippocampus.
Monks DA, Getsios S, MacCalman CD, Watson NV. Monks DA, et al. Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1312-6. doi: 10.1073/pnas.98.3.1312. Epub 2001 Jan 23. Proc Natl Acad Sci U S A. 2001. PMID: 11158636 Free PMC article. - Molecular biology of cadherins in the nervous system.
Dalseg AM, Gaardsvoll H, Bock E. Dalseg AM, et al. Mol Neurobiol. 1993 Fall-Winter;7(3-4):207-28. doi: 10.1007/BF02769176. Mol Neurobiol. 1993. PMID: 8179839 Review. - The formation of actin waves during regeneration after axonal lesion is enhanced by BDNF.
Difato F, Tsushima H, Pesce M, Benfenati F, Blau A, Chieregatti E. Difato F, et al. Sci Rep. 2011;1:183. doi: 10.1038/srep00183. Epub 2011 Dec 6. Sci Rep. 2011. PMID: 22355698 Free PMC article. - Axonal protein synthesis and degradation are necessary for efficient growth cone regeneration.
Verma P, Chierzi S, Codd AM, Campbell DS, Meyer RL, Holt CE, Fawcett JW. Verma P, et al. J Neurosci. 2005 Jan 12;25(2):331-42. doi: 10.1523/JNEUROSCI.3073-04.2005. J Neurosci. 2005. PMID: 15647476 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials