Effects of an Rb mutation in the mouse - PubMed (original) (raw)

. 1992 Sep 24;359(6393):295-300.

doi: 10.1038/359295a0.

Affiliations

• PMID: 1406933
• DOI: 10.1038/359295a0

Effects of an Rb mutation in the mouse

T Jacks et al. Nature. 1992.

Abstract

The retinoblastoma gene is mutated in several types of human cancer and is the best characterized of the tumour-suppressor genes. A mouse strain has been constructed in which one allele of Rb is disrupted. These heterozygous animals are not predisposed to retinoblastoma, but some display pituitary tumours arising from cells in which the wild-type Rb allele is absent. Embryos homozygous for the mutation die between days 14 and 15 of gestation, exhibiting neuronal cell death and defective erythropoiesis.

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Comment in

• Retinoblastoma. For our eyes only.
  Harlow E. Harlow E. Nature. 1992 Sep 24;359(6393):270-1. doi: 10.1038/359270a0. Nature. 1992. PMID: 1406928 No abstract available.

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