The role of swollen astrocytes in human brain lesions after edema--an immunohistochemical study using formalin-fixed paraffin-embedded sections - PubMed (original) (raw)

The role of swollen astrocytes in human brain lesions after edema--an immunohistochemical study using formalin-fixed paraffin-embedded sections

N Arai. Neurosci Lett. 1992.

Abstract

Swollen astrocytes (SAs) in the white matter after brain edema were immunohistochemically studied in cases with cerebral vascular events, brain tumor and protracted non-missile head injury. SAs showed a decrease in reactivity to glial fibrillary acidic protein (GFAP) and, on the other hand, were positive for laminin, an extracellular matrix glycoprotein known to be secreted by astrocytes. SAs in protracted lesions were strongly positive for both vimentin and plasma proteins including IgG, IgM, C3d and C4d. Remarkable vimentin expression in SAs, instead of GFAP, strongly suggests that SAs are not going to degenerate but are bearing up to regenerate in such circumstances. A number of vimentin-positive buttons also appeared in such protracted lesions, demonstrating disintegration of the processes of SAs. Immunohistochemical detection of plasma proteins in SAs are believed to indicate a facilitated activation in SAs to transform to macrophage-like cells and to act as phagocytes. In addition, demonstration of laminin may suggest hyperactivity of laminin production in SAs after both axonal injury and concomitant edema in order to stimulate neuritic regeneration.

PubMed Disclaimer

Cited by

Amyloid precursor protein induces reactive astrogliosis.
Jauregui GV, Vukić D, Onyango IG, Arias C, Novotný JS, Texlová K, Wang S, Kovačovicova KL, Polakova N, Zelinkova J, Čarna M, Strašil VL, Head BP, Havas D, Mistrik M, Zorec R, Verkhratsky A, Keegan L, O'Connel M, Rissman R, Stokin GB. Jauregui GV, et al. bioRxiv [Preprint]. 2023 Dec 18:2023.12.18.571817. doi: 10.1101/2023.12.18.571817. bioRxiv. 2023. PMID: 38187544 Free PMC article. Updated. Preprint.
Developing a mouse model of acute encephalopathy using low-dose lipopolysaccharide injection and hyperthermia treatment.
Kurata H, Saito K, Kawashima F, Ikenari T, Oguri M, Saito Y, Maegaki Y, Mori T. Kurata H, et al. Exp Biol Med (Maywood). 2019 Jun;244(9):743-751. doi: 10.1177/1535370219846497. Epub 2019 May 2. Exp Biol Med (Maywood). 2019. PMID: 31046452 Free PMC article.
Repetitive Transcranial Magnetic Stimulation Promotes Neural Stem Cell Proliferation and Differentiation after Intracerebral Hemorrhage in Mice.
Cui M, Ge H, Zeng H, Yan H, Zhang L, Feng H, Chen Y. Cui M, et al. Cell Transplant. 2019 May;28(5):568-584. doi: 10.1177/0963689719834870. Epub 2019 Mar 4. Cell Transplant. 2019. PMID: 30832493 Free PMC article.
Pre- and early postoperative GFAP serum levels in glioma and brain metastases.
Baumgarten P, Quick-Weller J, Gessler F, Wagner M, Tichy J, Forster MT, Foerch C, Seifert V, Mittelbronn M, Senft C. Baumgarten P, et al. J Neurooncol. 2018 Sep;139(3):541-546. doi: 10.1007/s11060-018-2898-1. Epub 2018 May 24. J Neurooncol. 2018. PMID: 29797180

MeSH terms

Substances

LinkOut - more resources

Full Text Sources
- Elsevier Science
Miscellaneous
- NCI CPTAC Assay Portal

The role of swollen astrocytes in human brain lesions after edema--an immunohistochemical study using formalin-fixed paraffin-embedded sections - PubMed (original) (raw)